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Your search keyword '"Diogo Garcia"' showing total 3 results
Start Over Author "Diogo Garcia" Journal molecular immunology
3 results on '"Diogo Garcia"'

3. CD4

Author

João Filipe Pereira, Vieira, Jamille Mirelle, de Oliveira Cardoso, Rory Cristiane Fortes, de Brito, Bruno Mendes, Roatt, Cláudia Martins, Carneiro, Diogo Garcia, Valadares, Rodrigo Dian, de Oliveira Aguiar-Soares, and Alexandre Barbosa, Reis

Subjects
CD4-Positive T-Lymphocytes, Macrophages, Green Fluorescent Proteins, CD8-Positive T-Lymphocytes, Nitric Oxide, Coculture Techniques, Interferon-gamma, Dogs, Leukocytes, Mononuclear, Animals, Leishmaniasis, Visceral, Dog Diseases, Interleukin-4, Leishmania infantum, Reactive Oxygen Species, Biomarkers
Abstract

Dogs are the most common domestic reservoir of Leishmania infantum, making canine visceral leishmaniasis (CVL) a serious public health issue. Identifying new methodologies that can mimic lymphoid and myeloid competence in naturally infected dogs could lower costs and save time in preliminary screenings of potential immunotherapeutic agents and vaccines against CVL. For that, we established a cell-to-cell communication approach between lymphocytes and myeloid cells from healthy, asymptomatic (infected, without apparent clinical signs) and symptomatic (infected with apparent clinical signs) dogs. Peripheral blood mononuclear cells (PBMC) from these dogs were used as source of CD4

Published
2022

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