7 results on '"Itoh, Kohji"'
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2. Innovative gene therapy for lysosomal neuraminidase 1 (NEU1) deficiencies
3. In vivo gene therapy for Tay-Sachs and Sandhoff diseases by utilizing AAV9 vector encoding modified HEXB
4. A novel glycotechnology to produce human lysosomal enzymes carrying synthetic N-glycans with terminal mannose 6-phosphate residues and application to enzyme placement therapy for lysosomal diseases
5. A transgenic silkworm overexpressing human lysosomal enzyme as a novel resource for producing recombinant glycobiologics and its application to development of enzyme replacement therapy for lysosomal diseases
6. Development of protease-resistant modified human β-hexosaminidase B and evaluation of intracerebroventricular replacement effects on GM2 gangliosidosis model mice
7. Replacement effects of human modified lysosomal β-hexosaminidase B on Tay-Sachs disease and Sandhoff disease models and imaging with novel pH-activatable fluorescent probes
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