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Your search keyword '"Xu, Wanping"' showing total 4 results
Start Over Author "Xu, Wanping" Journal molecular cell
4 results on '"Xu, Wanping"'

1. Asymmetric Hsp90 N Domain SUMOylation Recruits Aha1 and ATP-Competitive Inhibitors

Author

Mollapour, Mehdi, primary, Bourboulia, Dimitra, additional, Beebe, Kristin, additional, Woodford, Mark R., additional, Polier, Sigrun, additional, Hoang, Anthony, additional, Chelluri, Raju, additional, Li, Yu, additional, Guo, Ailan, additional, Lee, Min-Jung, additional, Fotooh-Abadi, Elham, additional, Khan, Sahar, additional, Prince, Thomas, additional, Miyajima, Naoto, additional, Yoshida, Soichiro, additional, Tsutsumi, Shinji, additional, Xu, Wanping, additional, Panaretou, Barry, additional, Stetler-Stevenson, William G., additional, Bratslavsky, Gennady, additional, Trepel, Jane B., additional, Prodromou, Chrisostomos, additional, and Neckers, Len, additional

Published
2014
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2. Dynamic Tyrosine Phosphorylation Modulates Cycling of the HSP90-P50CDC37-AHA1 Chaperone Machine

Author

Xu, Wanping, primary, Mollapour, Mehdi, additional, Prodromou, Chrisostomos, additional, Wang, Suiquan, additional, Scroggins, Bradley T., additional, Palchick, Zach, additional, Beebe, Kristin, additional, Siderius, Marco, additional, Lee, Min-Jung, additional, Couvillon, Anthony, additional, Trepel, Jane B., additional, Miyata, Yoshihiko, additional, Matts, Robert, additional, and Neckers, Len, additional

Published
2012
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3. Threonine 22 Phosphorylation Attenuates Hsp90 Interaction with Cochaperones and Affects Its Chaperone Activity

Author

Mollapour, Mehdi, primary, Tsutsumi, Shinji, additional, Truman, Andrew W., additional, Xu, Wanping, additional, Vaughan, Cara K., additional, Beebe, Kristin, additional, Konstantinova, Anna, additional, Vourganti, Srinivas, additional, Panaretou, Barry, additional, Piper, Peter W., additional, Trepel, Jane B., additional, Prodromou, Chrisostomos, additional, Pearl, Laurence H., additional, and Neckers, Len, additional

Published
2011
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4. Dynamic Tyrosine Phosphorylation Modulates Cycling of the HSP90-P50CDC37-AHA1 Chaperone Machine

Author

Xu, Wanping, Mollapour, Mehdi, Prodromou, Chrisostomos, Wang, Suiquan, Scroggins, Bradley T., Palchick, Zach, Beebe, Kristin, Siderius, Marco, Lee, Min-Jung, Couvillon, Anthony, Trepel, Jane B., Miyata, Yoshihiko, Matts, Robert, and Neckers, Len

Subjects
*TYROSINE, *PHOSPHORYLATION, *PROTEIN kinases, *MOLECULAR chaperones, *HEAT shock proteins, *HYDROLYSIS
Abstract

Summary: Many critical protein kinases rely on the Hsp90 chaperone machinery for stability and function. After initially forming a ternary complex with kinase client and the cochaperone p50Cdc37, Hsp90 proceeds through a cycle of conformational changes facilitated by ATP binding and hydrolysis. Progression through the chaperone cycle requires release of p50Cdc37 and recruitment of the ATPase activating cochaperone AHA1, but the molecular regulation of this complex process at the cellular level is poorly understood. We demonstrate that a series of tyrosine phosphorylation events, involving both p50Cdc37 and Hsp90, are minimally sufficient to provide directionality to the chaperone cycle. p50Cdc37 phosphorylation on Y4 and Y298 disrupts client-p50Cdc37 association, while Hsp90 phosphorylation on Y197 dissociates p50Cdc37 from Hsp90. Hsp90 phosphorylation on Y313 promotes recruitment of AHA1, which stimulates Hsp90 ATPase activity, furthering the chaperoning process. Finally, at completion of the chaperone cycle, Hsp90 Y627 phosphorylation induces dissociation of the client and remaining cochaperones. [Copyright &y& Elsevier]

Published
2012
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