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1. Hiding in the dark: pan-cancer characterization of expression and clinical relevance of CD40 to immune checkpoint blockade therapy.

Author

Yan, Chi and Richmond, Ann

Subjects
*IMMUNE checkpoint proteins, *MELANOMA, *PROGRAMMED cell death 1 receptors, *PROGRAMMED death-ligand 1, *IMMUNE response, *NEVUS
Abstract

Highlights: CD40 expression correlates with the type I anti-tumor response and better survival. Pan-cancer bioinformatics characterization reveals reduced CD40 expression in 11 cancer types, including RASmut melanoma compared to nevi. RAS mutation correlates with reduced CD40 expression in malignant melanoma. CD40 expression is associated with better response to immune checkpoint blockade therapy in melanoma. [ABSTRACT FROM AUTHOR]

Published
2021
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