Author: "Venessa T. Chin" / Journal: molecular & cellular oncology - Searchworks@Jio Institute Digital Library Search Results

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Start Over Author "Venessa T. Chin" Journal molecular & cellular oncology

Author: Venessa T. Chin, Claire Vennin, Paul Timpson, and Marina Pajic
Subjects: extracellular matrix, pancreatic cancer, rho gtpase, rock inhibitors, tailored therapy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract: Our recent publication demonstrates that transient inhibition of Rho-associated kinase signaling within stroma, significantly decreased in vivo primary tumor growth, metastasis and improved response to standard-of-care therapy in pancreatic cancer. Automated analysis of collagen organization in patient tumors may present a promising tool to predict response to our proposed treatment.
Published: 2017
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Author: Paul Timpson, Marina Pajic, Venessa T. Chin, and Claire Vennin
Subjects: 0301 basic medicine, Cancer Research, Pathology, medicine.medical_specialty, Stromal cell, pancreatic cancer, Biology, Metastasis, Extracellular matrix, 03 medical and health sciences, 0302 clinical medicine, Stroma, In vivo, Pancreatic cancer, medicine, In patient, ROCK inhibitors, Rho GTPase, medicine.disease, Primary tumor, 030104 developmental biology, 030220 oncology & carcinogenesis, Cancer research, Commentary, Molecular Medicine, tailored therapy
Abstract: Our recent publication demonstrates that transient inhibition of Rho-associated kinase signaling within stroma, significantly decreased in vivo primary tumor growth, metastasis and improved response to standard-of-care therapy in pancreatic cancer. Automated analysis of collagen organization in patient tumors may present a promising tool to predict response to our proposed treatment.
Published: 2017

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