1. Associations of dietary and serum magnesium with serum high-sensitivity C-reactive protein in early radiographic knee osteoarthritis patients
- Author
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Wei Luo, Guanghua Lei, Chao Zeng, Yi-lin Xiong, Shu-guang Gao, Jie Wei, Yusheng Li, Tuo Yang, Hui Li, and Wen-Feng Xiao
- Subjects
Adult ,Male ,medicine.medical_specialty ,Radiography ,chemistry.chemical_element ,030209 endocrinology & metabolism ,Osteoarthritis ,Logistic regression ,Dietary Magnesium ,Gastroenterology ,03 medical and health sciences ,0302 clinical medicine ,Rheumatology ,Internal medicine ,medicine ,Humans ,Magnesium ,030203 arthritis & rheumatology ,biology ,business.industry ,Confounding ,C-reactive protein ,Odds ratio ,Middle Aged ,Osteoarthritis, Knee ,medicine.disease ,Diet ,Surgery ,C-Reactive Protein ,Cross-Sectional Studies ,chemistry ,biology.protein ,Female ,business - Abstract
This study aimed to examine the associations of dietary magnesium (Mg) intake and serum Mg concentration with the high-sensitivity C-reactive protein (hsCRP) level in early radiographic knee osteoarthritis (OA) patients.Multivariable logistic regression was used to test the associations of dietary and serum Mg with the serum hsCRP in early radiographic knee OA patients after adjustment of a number of potential confounding factors.A total of 936 early radiographic knee OA patients were included. A significant association between dietary Mg intake and hsCRP was observed. The multivariable-adjusted odds ratio (OR) (95% CI) for elevated hsCRP (≥3.0 mg/l) in the second, third, fourth, and fifth dietary Mg intake quintile were 0.44 (95% CI: 0.24-0.82), 0.58 (95% CI: 0.31-1.10), 0.34 (95% CI: 0.15-0.77), and 0.19 (95% CI: 0.06-0.57), respectively, compared with the lowest (first) quintile, and p for trend was 0.01. A significant association between serum Mg concentration and hsCRP was observed. The multivariable-adjusted OR (95% CI) for elevated hsCRP in the second, third, fourth, and fifth serum Mg concentration quintile were 0.63 (95% CI: 0.35-1.12), 0.83 (95% CI: 0.50-1.39), 0.53 (95% CI: 0.31-0.91), and 0.46 (95% CI: 0.25-0.85), respectively, compared with the lowest quintile, and p for trend was 0.01.The present study indicated that both dietary and serum Mg were inversely associated with serum hsCRP in early radiographic knee OA patients.
- Published
- 2016