1. Triple-negative breast lobular carcinoma: a luminal androgen receptor carcinoma with specific ESRRA mutations
- Author
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Céline Charon-Barra, Corentin Richard, Laurent Arnould, Patrick Arveux, Hervé Bonnefoi, Françoise Beltjens, Catherine Loustalot, Emilie Degrolard-Courcet, Aurélie Bertaut, Anthony Bergeron, Gaëtan MacGrogan, Romain Boidot, Isabelle Desmoulins, Sophie Auriol, and Sylvain Ladoire
- Subjects
0301 basic medicine ,Oncology ,Adult ,medicine.medical_specialty ,Pathology ,Receptor, ErbB-2 ,Lobular carcinoma ,DNA Mutational Analysis ,Triple Negative Breast Neoplasms ,Article ,Pathology and Forensic Medicine ,03 medical and health sciences ,Basal (phylogenetics) ,Phosphatidylinositol 3-Kinases ,0302 clinical medicine ,Breast cancer ,Internal medicine ,medicine ,Carcinoma ,Humans ,skin and connective tissue diseases ,Survival analysis ,Aged ,Aged, 80 and over ,business.industry ,Middle Aged ,medicine.disease ,Androgen receptor ,body regions ,Carcinoma, Lobular ,030104 developmental biology ,Pleomorphism (cytology) ,Receptors, Estrogen ,Receptors, Androgen ,030220 oncology & carcinogenesis ,Invasive lobular carcinoma ,Mutation ,Female ,business - Abstract
Primary triple-negative invasive lobular breast carcinomas (TN-ILCs), which do not express hormone receptors and HER2 at diagnosis, are rare and poorly known. In this study, we analyzed the largest TN-ILC series ever reported in the literature, in comparison to phenotypically similar breast tumor subtypes: triple-negative invasive ductal carcinoma (TN-IDC) and hormone receptor-positive invasive lobular carcinoma (HR + ILC). All primary TN-ILCs registered in our database between 2000 and 2018 (n = 38) were compared to tumors from control groups, matched by stage and Elston/Ellis grade, with regard to clinical, pathologic, and immunohistochemical characteristics. A comparative molecular analysis (whole-exome and RNA sequencing using next-generation technology) was also performed. We found that TN-ILC patients were older than those with HR + ILC (P = 0.002) or TN-IDC (P
- Published
- 2020