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The authors reviewed literature data regarding risk factors of cancer in order to produce a software that could identify asymptomatic subjects at "neoplastic risk" by means of the analysis of the relative risk (RR) of each factor of his/her life-style. More in detail, the relationship between diet and cancer, tobacco use, alcohol consumption, sexual behaviour, parity and other obstetric-gynecologic aspects, medications, occupational hazards, environmental pollution and genetic susceptibility were reviewed. A complex multi-parametric evaluation system was realized to calculate risk of cancers through computerized elaboration. The program operates on anamnestic, objective and instrumental data derived from a clinical data-base.

The Authors assess investments and resources appropriated for research and technological innovation and highlight the imbalance existing between the areas of Central-Northern and Southern Italy. In particular, data relative to Comprehensive Health Care Institutes (IRCCS) fully confirm the diversity between the Central-North and the South; indeed, in terms of economic resources and personnel, totals in this latter region amount to 13.8% and 10.5% of national figures respectively. The role that IRCCSes might assume within the framework of an effective program of the re-qualification and development of scientific research and health care in Italy, especially in Southern areas, is thus confirmed.

The aim of the present study is to describe the constitutions and functions of Ethics Committees and Institutional Review Boards. In particular, the experience of the National Institute for Cancer Research of Genoa in which the Authors carry out their activity is presented.

The qualities of Comprehensive Health Care Institutes facilities established to foster, carry out and coordinate activities of scientific research and assistance in the field of biomedicine are described. At present there are 23 centers, their activity being based on two fundamental features: 1) topical research in specific themes characterizing the role these Institutes continuously play; 2) specialized research concerning subjects of particular interest and/or urgency suggested by the Ministry of Health.

The role of surgery in head and neck cancer treatment is now well established, as it appears the most effective approach to such patients, while other therapies (i.e. chemotherapy, radiotherapy) can be of some help as second choice procedures. Surgery demonstrates however its own pitfalls, as it can often cause secondary anatomo-functional defects. The main problems appear to be related to the impossibility of physiological feeding following composite resection for oral cancer. An immediate reconstruction by transposition of myocutaneous flaps is of the utmost importance, as it reestablishes the preoperative condition lessening hospitalization time and postoperative disabilities. Neurological lesions, an unfrequent major complication of cervical lymphadenectomy, can cover a wide range of seriousness, from hardly detectable sensorial deficits to the impossibility of spontaneous ventilation. In this paper the Authors, on the basis of their experience, describe the measures to be taken in order to avoid secondary lesions (or to minimize their effects) in head and neck cancer surgery.

The authors review the epidemiologic and etiopathogenetic aspects of AIDS, in agreement with data published in december by the Center for Disease Control and by the WHO for the States, Europe and Italy. In their experience twenty-one patients, with clinical clues of AIDS, undergoing lymph node biopsy, have been analysed (18 LAS-ARC and 3 AIDS) and the role of prophylaxis for the surgical approach to the patient with aids or related syndrome has been underlined.

An investigation on smoking habits of teachers of secondary and high schools allowed the collection of very interesting and useful data for the organization of post-graduate up-date courses and health education programs. Smokers' proportion remains still high, as 35% of males and 30% of females teachers are smokers; this situation is different in other countries, where an inverse relationship exists between smoking habit and economic welfare and cultural level. The number of daily-cigarettes was rather low only in females teachers, as 50% smoked less than 5-10 daily-cigarettes. Teachers' interviews suggested the high degree of interest in the organization of health education programs and courses on smoking, with special regard to the courses on smoking, with special regard to the methodology that is required for prevention programs in the school. The high attendance to the courses, the quantity and quality of teachers' reports on these problems and the practical application in school environment of these theoretical concepts confirmed the reliability and effectiveness of this methodologic approach.

An antismoking campaign aimed at the 9-18 year old Genoese school population in 1981-1985 is described. The high percentage of smokers in Italy and the worryingly early age at which the habit is acquired suggested the need for a carefully prepared ongoing programme of primary prevention that would not be limited to occasional speeches. Part of the programme was also directed towards school health officers, teachers and families for whom seminars and refresher courses and topics appropriate for each group were organised. The dangers of smoking framed in a broader context were described and debater before a total of 26,000 school children in 4 years. The results that can only now be examined due to initial difficulties in implementing the programme show that out of 4613 smokers involved in the programme 29.8% stopped smoking after a year. Significantly in the same group and in the same period only 2.5% of the school children began to smoke. In contrast 15.8% new smokers were found in the control group. Further checks on a wider sample are scheduled in order to verify and confirm the results presented.

A study on 285 students and teachers of a nurse professional school was undertaken in two hospital of Genoa. A questionnaire proposed by World Health Organization and by Italian League Against Cancer was employed to collect data on smoking habits and behaviour. Subjects included in the present study were selectively chosen as they are in a transitional phase between school application and working environment within the hospital practice. Although these sample of hospital personnel showed a slow trend toward quit smoking, the rates of smokers are rather high, both in the youth (55%) and in the teachers. Our results showed that 87% of subjects interview agreed with the necessity to avoid smoking within the hospital environment; young nurses generally lack a specific knowledge about the hazard of smoking and more detailed information is requested for a correct education and prevention of patients' health.