This paper presents the results of investigation of the effect of slag composition and the slag basicity, in the process of smelting of sulfide copper concentrate, on the distribution coefficient (LS=M Me ) for the following elements: Cu, Bi, Co, Au, Ag, Zn, Pb, Ni, As, Sb, Se, and Te. The research was conducted under the industrial operating conditions of the copper smelter in Bor, Serbia. High values for the coefficient of determination (R2> 0.6) for the LS=M Me dependence on the slag composition were obtained, which presents a high degree of fitting. In the case of the dependence of LS=M Me on the slag basicity, obtained R2 values were much lower, due to the much smaller statistical sample.