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Your search keyword '"Diego Ingrosso"' showing total 4 results
Start Over Author "Diego Ingrosso" Journal mineral and electrolyte metabolism
4 results on '"Diego Ingrosso"'

1. Title Pages / Contents

Author

Guy Laurent, Giuseppe Remuzzi, Walter H. Hörl, Martin K. Kuhlmann, Raymond M. Hakim, Lara B. Pupim, Eduardo Slatopolsky, Marina Noris, James L. Bailey, James Moberly, Alessandra F. Perna, Rajnish Mehrotra, Gere Sunder-Plassmann, Patrizia Galletti, X. Wang, Pasquale Castaldo, Diego Ingrosso, Shi-Nong Wang, Christof Ulrich, Pamela S. Kent, Per-Ola Attman, Carolyn Knight-Gibson, Toshimitsu Niwa, Tilman B. Drüeke, Alin Sela-Brown, Jonas Bergström, Charles Chazot, Guillaume Jean, Ann-Cathrine Johansson, E. van Etten, Manuela Födinger, William E. Mitch, Peter Stenvinkel, Bernd Krüger, Werner Riegel, Tally Naveh-Many, Marsha Wolfson, T. Alp Ikizler, Ola Samuelsson, Jan Galle, Rastislav Dzúrik, Rhoda Makoff, S. Segaert, S.R. Price, Shaul G. Massry, Takashi Miyazaki, George A. Kaysen, Zora Krivošíková, Xiaonan Wang, Petar Alaupovic, Iain C. Macdougall, Franciszek Kokot, August Heidland, Hans Köhler, Natale De Santo, Christoph Wanner, Anna Mortelmans, S. Price, Felix Schmidt, Gerald Münch, Jie Du, C. Mathieu, Christina Kilates, Francis Dumler, Joel D. Kopple, Reinhard Schinzel, Katarína Derzsiová, Isao Aoyama, Justin Silver, Alex J. Brown, Jutta Paßlick-Deetjen, Michael Jones, Christian Friedrichsohn, R. Bouillon, Eva Žemberová, Sistiana Aiello, Wilfred Druml, Miroslav Mydlík, Katarína Šebeková, L. Verlinden, A. Verstuyf, Rafat Ficek, Janine LaPage, Karl D. Nolph, Raymond Vanholder, Raimund Hirschberg, Bernard Charra, and Heidi Buchmayer

Subjects
Polymer science, Chemistry, Endocrinology, Diabetes and Metabolism, Mineralogy, Biochemistry
Published
1999

2. Homocysteine, a new crucial element in the pathogenesis of uremic cardiovascular complications

Author

Alessandra F. Perna, Vincenzo Zappia, P Castaldo, Diego Ingrosso, N. G. De Santo, Patrizia Galletti, Perna, Alessandra, Ingrosso, Diego, Castaldo, P, DE SANTO, Ng, Galletti, P, and Zappia, V.

Subjects
congenital, hereditary, and neonatal diseases and abnormalities, medicine.medical_specialty, Hyperhomocysteinemia, Homocysteine, Endocrinology, Diabetes and Metabolism, Bioinformatics, Biochemistry, Cardiovascular risk factor, Pathogenesis, chemistry.chemical_compound, Folic Acid, Risk Factors, Internal medicine, medicine, Humans, Myocardial infarction, Risk factor, Kidney transplantation, Uremia, business.industry, nutritional and metabolic diseases, medicine.disease, Kidney Transplantation, Endocrinology, chemistry, Adenosylhomocysteine, Cardiovascular Diseases, cardiovascular system, Kidney Failure, Chronic, Observational study, business, Folate therapy
Abstract

Most large observational studies available today establish that moderate hyperhomocysteinemia, either genetically or nutritionally determined, is an independent risk factor for myocardial infarction, stroke, and thromboembolic disease. This is also true for chronic renal failure patients, who exhibit a high prevalence of hyperhomocysteinemia (85–100%), which reaches high plasma concentrations (20–40 µM, while control values range between 8 and 12 µM−). After a renal transplant, homocysteine levels decrease, but tend to be higher than normal. The cause of hyperhomocysteinemia in renal failure is still obscure, since recent data have questioned the previous notion that a net homocysteine renal extraction and/or excretion take place in man. No matter the cause of its increase, the sulfur amino acid homocysteine is thought to induce an increment in cardiovascular risk through three basic biochemical mechanisms: (1) homocysteine oxidation, with H2O2 generation; (2) hypomethylation through S-adenosylhomocysteine accumulation, and (3) protein acylation by homocysteine thiolactone. The final result is membrane protein damage, endothelial damage, and endothelial cell growth inhibition, among other effects. Hyperhomocysteinemia, in general, is susceptible of therapeutic intervention with the vitamins involved in its metabolism. Depending on the cause, vitamin B6, vitamin B12, betaine, and/or folic acid can be effectively utilized. Chronic renal failure patients benefit from folic acid in high dosage: 1–2 mg are usually not effective (‘relative folate resistance’), while 5–15 mg reduce homocysteine levels to a ‘normative’ range (M) in a substantial group of patients. Good results are also obtained in transplant patients, best with a combination of folic and vitamin B6. The results of the interventional trials focusing on the possible reduction in cardiovascular risk after homocysteine-lowering therapy, both in the general population and in end-stage renal disease, are expected soon, as well as the genetic and biochemical studies in suitable models, with the aim to clarify the cause-effect link suggested by the numerous observational and basic science studies.

Published
1999

3. Subject Index Vol. 25, 1999

Author

Carolyn Knight-Gibson, E. van Etten, George A. Kaysen, James L. Bailey, James Moberly, Jie Du, Gere Sunder-Plassmann, Reinhard Schinzel, Bernd Krüger, Guy Laurent, Bernard Charra, Hans Köhler, Rhoda Makoff, Felix Schmidt, Karl D. Nolph, Lara B. Pupim, C. Mathieu, Guillaume Jean, Zora Krivošíková, August Heidland, Eduardo Slatopolsky, Toshimitsu Niwa, Christof Ulrich, Francis Dumler, L. Verlinden, A. Verstuyf, Alin Sela-Brown, Isao Aoyama, Tilman B. Drüeke, S.R. Price, William E. Mitch, Gerald Münch, Xiaonan Wang, S. Segaert, Jonas Bergström, Ola Samuelsson, Janine LaPage, Giuseppe Remuzzi, Marina Noris, Alessandra F. Perna, Katarína Šebeková, S. Price, Tally Naveh-Many, Jan Galle, Rafat Ficek, Takashi Miyazaki, Justin Silver, Natale De Santo, Marsha Wolfson, Christina Kilates, T. Alp Ikizler, Eva Žemberová, Heidi Buchmayer, Alex J. Brown, Sistiana Aiello, R. Bouillon, Joel D. Kopple, Michael Jones, Jutta Paßlick-Deetjen, Pasquale Castaldo, Raymond M. Hakim, Christian Friedrichsohn, Charles Chazot, Walter H. Hörl, Diego Ingrosso, Patrizia Galletti, X. Wang, Wilfred Druml, Per-Ola Attman, Manuela Födinger, Raymond Vanholder, Raimund Hirschberg, Petar Alaupovic, Martin K. Kuhlmann, Rajnish Mehrotra, Shi-Nong Wang, Christoph Wanner, Miroslav Mydlík, Anna Mortelmans, Iain C. Macdougall, Werner Riegel, Shaul G. Massry, Franciszek Kokot, Peter Stenvinkel, Ann-Cathrine Johansson, Rastislav Dzúrik, Katarína Derzsiová, and Pamela S. Kent

Subjects
Index (economics), Anthropology, Chemistry, Endocrinology, Diabetes and Metabolism, Mineralogy, Subject (documents), Biochemistry
Published
1999

4. Contents Vol. 25, 1999

Author

Tally Naveh-Many, Rafat Ficek, Guy Laurent, Raymond Vanholder, Christoph Wanner, Reinhard Schinzel, Bernd Krüger, Raimund Hirschberg, Anna Mortelmans, Felix Schmidt, August Heidland, C. Mathieu, Justin Silver, Karl D. Nolph, Francis Dumler, Gerald Münch, Zora Krivošíková, L. Verlinden, A. Verstuyf, Michael Jones, Alessandra F. Perna, Ola Samuelsson, Bernard Charra, Eva Žemberová, Pasquale Castaldo, Janine LaPage, Katarína Šebeková, Sistiana Aiello, Christof Ulrich, Heidi Buchmayer, Toshimitsu Niwa, Joel D. Kopple, Katarína Derzsiová, Diego Ingrosso, Marsha Wolfson, Martin K. Kuhlmann, Iain C. Macdougall, Jutta Paßlick-Deetjen, Tilman B. Drüeke, E. van Etten, Shi-Nong Wang, Marina Noris, Rajnish Mehrotra, Wilfred Druml, Per-Ola Attman, Christian Friedrichsohn, Alex J. Brown, Carolyn Knight-Gibson, R. Bouillon, Eduardo Slatopolsky, S.R. Price, Charles Chazot, Lara B. Pupim, Giuseppe Remuzzi, Xiaonan Wang, Raymond M. Hakim, Patrizia Galletti, X. Wang, T. Alp Ikizler, Guillaume Jean, Werner Riegel, Peter Stenvinkel, Ann-Cathrine Johansson, Pamela S. Kent, Petar Alaupovic, Jonas Bergström, Jan Galle, James L. Bailey, James Moberly, Gere Sunder-Plassmann, Rastislav Dzúrik, Shaul G. Massry, Franciszek Kokot, George A. Kaysen, Jie Du, Miroslav Mydlík, Hans Köhler, Rhoda Makoff, Takashi Miyazaki, Natale De Santo, Christina Kilates, Isao Aoyama, William E. Mitch, S. Segaert, S. Price, Alin Sela-Brown, Walter H. Hörl, and Manuela Födinger

Subjects
Endocrinology, Diabetes and Metabolism, Biochemistry
Published
1999

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