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Start Over Author "Fu-Yang, Zhang" Journal military medical research
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1. Targeting PPARα in low ambient temperature exposure-induced cardiac dysfunction and remodeling

Author

Xi-Yao Chen, Yang Jiao, and Fu-Yang Zhang

Subjects
Low ambient temperature, Cardiac dysfunction, Remodeling, Peroxisome proliferator-activated receptor-α, Fatty acid metabolism, Medicine (General), R5-920, Military Science
Abstract

Abstract The present study demonstrates that the down-regulation of peroxisome proliferator-activated receptor-α (PPARα) results in chronic low ambient temperature (LT) exposure-induced cardiac dysfunction and remodeling, emphasizing the therapeutic potential of PPARα activation strategies (e.g. fenofibrate treatment) in LT-associated cardiac injury.

Published
2021
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