15 results on '"Nasseri-Moghaddam, Siavosh"'
Search Results
2. A Supporting System for Management of Patients with Inflammatory Bowel Disease during COVID-19 Outbreak: Iranian Experience-Study Protocol
- Author
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Anushiravani, Amir, Vahedi, Homayoon, Fakheri, Hafez, Mansour-ghanaei, Fariborz, Maleki, Iradj, Nasseri-Moghaddam, Siavosh, Vosoghinia, Hasan, Ghadir, Mohammad Reza, Hormati, Ahmad, Aminisani, Nayyereh, Radmard, Amir Reza, Khosravi, Bardia, Saberzadeh-Ardestani, Bahar, Malekzadeh, Masoud, Alatab, Sudabeh, Sadeghi, Anahita, Salahi, Sarvenaz, Malekzadeh, Reza, and Sima, Ali Reza
- Subjects
COVID-19 ,Original Article ,Care ,digestive system diseases ,Protocols ,Inflammatory bowel disease - Abstract
BACKGROUND The COVID-19 pandemic has affected the health care infrastructure dramatically, with abundant resources necessarily being redirected to COVID-19 patients and their care. Also, patients with chronic diseases like inflammatory bowel disease (IBD) may be affected in several ways during this pandemic. METHODS We used the Iranian registry of Crohn's and colitis (IRCC) infrastructure. We called and sent messages to follow-up and support the care of all registered patients. Besides, we prepared and distributed educational materials for these patients and physicians to reduce the risk of COVID-19 infection. We risk-stratified them and prepared outpatient clinics and hospitalization guidance for IBD patients. RESULTS Of 13165 Iranian patients with IBD, 51 have been diagnosed as having COVID-19. IBD patients made 1920 hotline calls. Among the patients with suspicious presentations, 14 COVID-19 infections were diagnosed. Additionally, 1782 patients with IBD from five provinces actively phone-called among whom 28 definite cases were diagnosed. CONCLUSION IBD patients' follow-up could help in diagnosing the affected IBD patients with COVID-19. Additionally, the performance of protective actions and preparing the patients and physicians for decisive proceedings are the principles of protection of IBD patients.
- Published
- 2020
3. Post-infectious Irritable Bowel Syndrome: A Narrative Review
- Author
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Sadeghi, Anahita, primary, Biglari, Mohammad, additional, and Nasseri Moghaddam, Siavosh, additional
- Published
- 2019
- Full Text
- View/download PDF
4. Minimum Requirements for Reporting Fecal Microbiota Transplant Trial
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Moossavi, Shirin, Bishehsari, Faraz, Ansari, Reza, Vahedi, Homayoon, Nasseri-Moghaddam, Siavosh, Merat, Shahin, Sobhani, Iradj, Keshavarzian, Ali, and Malekzadeh, Reza
- Subjects
Brief Report - Published
- 2015
5. Oral Nitrate Reductase Activity Is Not Associated with Development of Non-Alcoholic Fatty Liver Disease (NAFLD) and Non-Alcoholic Steatohepatitis (NASH): A Pilot Study
- Author
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Barzin, Gilda, Merat, Shahin, Nokhbeh-Zaeem, Habibeh, Saniee, Parastoo, Pedramnia, Shahrzad, Mostashfi Habibabadi, Ali, and Nasseri-Moghaddam, Siavosh
- Subjects
NAFLD ,Nitrate Reductase Activity ,NASH ,nutritional and metabolic diseases ,Original Article ,GERD ,digestive system ,digestive system diseases ,Oral Bacterial Flora - Abstract
BACKGROUND NAFLD/NASH is a manifestation of metabolic syndrome and is associated with obesity/overweight. Not all obese/overweight individuals develop NASH. Gastro-esophageal reflux disease (GERD) is considered a gastrointestinal manifestation of the metabolic syndrome and is associated with obesity/overweight. Again not all obese/overweight individuals develop GERD. Recent data show association of dietary nitrate content and oral nitrate reductase activity (NRA) with GERD. Nitrates need to be converted to nitrite (done in human beings by nitrate reductase of oral bacteria exclusively) to be active in metabolic pathways. OBJECTIVE To assess the relation between NASH/NAFLD and oral NRA. METHODS Oral NRA was measured in individuals with NASH (compatible abdominal ultrasound and two elevated ALT/AST levels over six months) and was compared with that of those without NASH. Oral NRA was measured according to a previously reported protocol. RESULTS Eleven NASH patients and twelve controls were enrolled. Mean oral NRA activity were 2.82 vs. 3.51 μg nitrite-N formed per person per minute for cases and controls respectively (p=0.46). CONCLUSION According to our data, oral nitrite production is not different between individual swith and without NASH.
- Published
- 2014
6. Eosinophilic Gastroenteritis: A Case Series from Iran
- Author
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Bagheri, Mohammad, Ashrafi, Mandana, Mohamadnejad, Mehdi, Abdollahzadeh Hosseini, Leila, Nasseri-Moghaddam, Siavosh, Merat, Shahin, Saberfiroozi, Mehdi, Sotoudeh, Masoud, and Malekzadeh, Reza
- Subjects
Eosinophils ,Esophagus ,Eosinophilic gastroenteritis ,Original Article ,Small intestine - Abstract
BACKGROUND Eosinophilic gastroenteritis (EG) is a rare inflammatory disorder of the gastrointestinal (GI) tract. There have been several case series of patients with EG from the western world and East Asia. However, there has not been a report of patients with EG from the Middle East region. The aim of this study is to describe clinical characteristics and treatment response in a series of EG patients from Iran. METHODS We retrospectively reviewed charts with a diagnosis of EG from 1997 to 2010 at Shariati Hospital and the private clinics of the authors. Clinical characteristics of the patients were evaluated, and the treatment response and relapse rate were assessed. RESULTS Twenty-two patients (9 male) with EG were identified. Mean age of the patients was 45.1±15.5 (range: 27-75) years. Median duration between symptom onset and diagnosis was 12 (range 1- 48) months. Twenty (90%) patients had mucosal involvement, one (5%) had muscular involvement and one (5%) had subserosal involvement. Patients were followed for a median duration of 36.5 (range 4-123) months. Two patients had spontaneous remission with supportive care. The remaining 20 patients responded well to oral corticosteroid treatments. The relapse rate was 33%. Episodes of relapse were successfully controlled with a repeat course of corticosteroids. Two patients with several relapses required maintenance treatment with azathioprine. CONCLUSION The clinical characteristics and treatment responses of EG patients from Iran are similar to reports from other parts of the world. Patients need to undergo close follow up after treatment to detect early signs of relapse.
- Published
- 2011
7. Mean Polyp per Patient Is an Accurate and Readily Obtainable Surrogate for Adenoma Detection Rate: Results from an Opportunistic Screening Colonoscopy Program.
- Author
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Delavari, Alireza, Salimzadeh, Hamideh, Rakhshankhah, Elham Sobh, Bishehsari, Faraz, Delavari, Farnaz, Moossavi, Shirin, Khosravi, Pejman, Nasseri-Moghaddam, Siavosh, Merat, Shahin, Ansari, Reza, Vahedi, Homayoon, Shahbazkhani, Bijan, Saberifiroozi, Mehdi, Sotoudeh, Masoud, and Malekzadeh, Reza
- Abstract
BACKGROUND The incidence of colorectal cancer is rising in several developing countries. In the absence of integrated endoscopy and pathology databases, adenoma detection rate (ADR), as a validated quality indicator of screening colonoscopy, is generally difficult to obtain in practice. We aimed to measure the correlation of polyp-related indicators with ADR in order to identify the most accurate surrogate(s) of ADR in routine practice. METHODS We retrospectively reviewed the endoscopic and histopathological findings of patients who underwent colonoscopy at a tertiary gastrointestinal clinic. The overall ADR and advanced-ADR were calculated using patient-level data. The Pearson's correlation coefficient (r) was applied to measure the strength of the correlation between the quality metrics obtained by endoscopists. RESULTS A total of 713 asymptomatic adults aged 50 and older who underwent their first-time screening colonoscopy were included in this study. The ADR and advanced-ADR were 33.00% (95% CI: 29.52-36.54) and 13.18% (95% CI: 10.79-15.90), respectively. We observed good correlations between polyp detection rate (PDR) and ADR (r=0.93), and mean number of polyp per patient (MPP) and ADR (r=0.88) throughout the colon. There was a positive, yet insignificant correlation between advanced ADRs and non-advanced ADRs (r=0.42, p=0.35). CONCLUSION MPP is strongly correlated with ADR, and can be considered as a reliable and readily obtainable proxy for ADR in opportunistic screening colonoscopy programs. [ABSTRACT FROM AUTHOR]
- Published
- 2015
8. Gastroesophageal Reflux Disease and overall and Cause-specific Mortality: A Prospective Study of 50000 Individuals.
- Author
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Islami, Farhad, Pourshams, Akram, Nasseri-Moghaddam, Siavosh, Khademi, Hooman, Poutschi, Hossein, Khoshnia, Masoud, Norouzi, Alireza, Amiriani, Taghi, Sohrabpour, Amir Ali, Aliasgari, Ali, Jafari, Elham, Semnani, Shahryar, Abnet, Christian C., Pharaoh, Paul D., Brennan, Paul, Kamangar, Farin, Dawsey, Sanford M., Boffetta, Paolo, and Malekzadeh, Reza
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CARDIOVASCULAR diseases ,CAUSES of death ,ESOPHAGEAL tumors ,GASTROESOPHAGEAL reflux ,LONGITUDINAL method - Abstract
BACKGROUND Only a few studies in Western countries have investigated the association between gastroesophageal reflux disease (GERD) and mortality at the general population level and they have shown mixed results. This study investigated the association between GERD symptoms and overall and cause-specific mortality in a large prospective population-based study in Golestan Province, Iran. METHODS Baseline data on frequency, onset time, and patient-perceived severity of GERD symptoms were available for 50001 participants in the Golestan Cohort Study (GCS). We identified 3107 deaths (including 1146 circulatory and 470 cancer-related) with an average follow-up of 6.4 years and calculated hazard ratios (HR) and 95% confidence intervals (CI) adjusted for multiple potential confounders. RESULTS Severe daily symptoms (defined as symptoms interfering with daily work or causing nighttime awakenings on a daily bases, reported by 4.3% of participants) were associated with cancer mortality (HR 1.48, 95% CI: 1.04-2.05). This increase was too small to noticeably affect overall mortality. Mortality was not associated with onset time or frequency of GERD and was not increased with mild to moderate symptoms. CONCLUSION We have observed an association with GERD and increased cancer mortality in a small group of individuals that had severe symptoms. Most patients with mild to moderate GERD can be re-assured that their symptoms are not associated with increased mortality. [ABSTRACT FROM AUTHOR]
- Published
- 2014
9. Serum Cystatin-C Is Not Superior to Serum Creatinine in Predicting Glomerular Filtration Rate in Cirrhotic Patients.
- Author
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Nasseri-Moghaddam, Siavosh, Ganji, Mohamad-Reza, Kochari, Mohammad-Reza, and Tofangchiha, Shahnaz
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CIRRHOSIS of the liver , *STATISTICAL correlation , *CREATININE , *GLOMERULAR filtration rate , *PROTEINS , *STATISTICS , *DATA analysis , *RECEIVER operating characteristic curves , *DATA analysis software , *DIAGNOSIS - Abstract
BACKGROUND Assessment of glomerular filtration rate (GFR) by common creatinine-based methods is potentially inaccurate in patients with cirrhosis. Cirrhotic patients have several underlying conditions that contribute to falsely low serum creatinine concentrations, even in the presence of moderate to severe renal impairment. Therefore creatinine-based methods usually overestimate true GFR in these patients. Cystatin-C is a low molecular weight protein and an endogenous marker of GFR. We compared the accuracy of plasma cystatin-C and creatinine in assessing renal function in cirrhotic patients. METHODS We serially enrolled cirrhotic patients with stable renal function admitted in our ward if they met the inclusion criteria and consented to participate. Child- Pugh (CP) score was calculated for all patients. GFR was calculated using serum creatinine, serum cystatin-C, and 99m TC-DTPA clearance with the last one serving as the gold standard. The area under curve (AUC) on receiver- operating characteristic curves (ROC) were used to assess the diagnostic accuracy of each calculated GFR with that measured by DTPA. RESULTS Fourty-eight patients were enrolled (32 males, 66.7%). Nine were in class-A, 20 in class-B and 19 in class-C of CP. Cystatin-C did not perform well in predicting the true GFR, while serum creatinine performed relatively accurately at GFR<80ml/min (AUC=0.764, p=0.004). Serum creatinine at a cutoff of 1.4 mg/ dl was 20% sensitive & 92% specific and with at a cutoff of 0.9 mg/dl was 77% sensitive & 72% specific for diagnosis of impaired renal function. Cystatin-C could not predict GFR effectively even after stratification for CP score, gender, and BMI. Serum creatinine could predict GFR<65ml/min in females (ROC curve AUC=0.844, p=0.045). In those with BMI>20 kg/m2 a GFR<80 ml/min could also be predicted by serum creatinine (ROC curve AUC=0.739,/p=0.034). It also could predict GFR<80ml/min in patients with CP class A & B (ROC curve AUC=0.795,/>=0.01), but not in patients with CP class C. CONCLUSION Neither serum creatinine nor Cystatin-C are good predictors of GFR in cirrhotic patients, although serum creatinine seems to perform better in selected subgroups. [ABSTRACT FROM AUTHOR]
- Published
- 2013
10. Cyclosporine-A Versus Prednisolone for Induction of Remission in Auto-immune Hepatitis: Interim Analysis Report of a Randomized Controlled Trial.
- Author
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Nasseri-Moghaddam, Siavosh, Nikfam, Sepideh, Karimian, Saied, Khashayar, Patricia, and Malekzadeh, Reza
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PREDNISOLONE , *RESEARCH methodology , *CHRONIC active hepatitis , *CYCLOSPORINE , *RANDOMIZED controlled trials , *ENZYME-linked immunosorbent assay , *DISEASE remission - Abstract
BACKGROUND Corticosteroids are used to induce remission in auto-immune hepatitis. They are not universally effective; therefore, alternative treatments are needed. In this study Cysclosporine-A has been compared with prednisolone as an alternative treatment in a randomized controlled trial. This paper is an interim analysis of an ongoing clinical trial. METHODS Sixteen years and older consenting patients were enrolled. Group-A received prednisolone and group-B cyclosporine-A according to a preset protocol and followed at regular intervals for 48 weeks. Final assessment was done at week 48. Primary outcome was response rate as defined below. "Complete response" was defined as achieving AST and ALT in the normal range and absence of any clinical signs of deterioration, and partial response was defined as a decrease in AST and ALT by less than half of their original values but not to within normal limit. Non-responding ones at week eight were switched to the other arm. RESULTS Thirty-nine patients were enrolled (24 group-A, 9 male). Mean AST and ALT at baseline were higher in group-B, but other variables were comparable. At week 12, 34.8% and 64.3% of group-A and B had achieved AST and ALT in the normal range (less than 40 IU/L) respectively (p=0.081). Corresponding figures at week 48 were 50.0% and 47.6% (p=0.62 & 0.48 respectively). At week 12, 86.9% and 85.7% of patients had AST and ALT levels less than twice upper normal limit in groups-A and B respectively (p=0.54 & 0.42). Corresponding figures at week 48 were 90.0% for both groups. There was one treatment failure in group-B which did not respond to prednisolone either. Serious adverse events (death and liver transplantation) occurred in group-A only. Serum creatinine did not change during the study period in either group. CONCLUSION According to our data, Cyclosporine-A is as effective as prednisolone for induction of remission in AIH. Adverse events and serious adverse events were more common with prednisolone. [ABSTRACT FROM AUTHOR]
- Published
- 2013
11. Probiotic vs. Placebo in Irritable Bowel Syndrome: A Randomized Controlled Trial.
- Author
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Amirimani, Behnaz, Nikfam, Sepideh, Albjai, Maryam, Vahedi, Sara, Nasseri-Moghaddam, Siavosh, Sharafkhah, Maryam, Ansari, Reza, and Vahedi, Homyoon
- Subjects
IRRITABLE colon treatment ,PLACEBOS ,THERAPEUTIC use of probiotics ,CHI-squared test ,COMPARATIVE studies ,LACTOBACILLUS ,RANDOMIZED controlled trials ,REPEATED measures design ,DATA analysis software - Abstract
BACKGROUND This study assesses the potential effect of Lactobacillus reuteri as a single strain probiotic preparation (Biogaia®) on irritable bowel syndrome (IBS). METHODS J Patients diagnosed with IBS who fulfilled Rome III criteria and consented to participate in this study were randomized to receive either the probiotic or an identical placebo once daily for four weeks. Patients used a questionnaire to record any symptoms and adverse reactions over a one-week run-in period and during the final two weeks of intervention. For each group, we calculated the differences between mean scores of the variables and compared the results between groups. RESULTS Frequency of defecation increased in the Biogaia® group and decreased in the placebo group meaningfully. But There were no significant difference in the two groups in other terms of bloating, sense of urgency for defecation, abdominal pain, stool shape, quality of defecation, sense of incomplete evacuation, and treatment satisfaction. CONCLUSION The frequency of defecation increased in the Biogaia® group and decreased in the placebo group, however this study did not classify patients according to diarrhea or constipated subgroups, the efficacy of this drug is not clear. Hence Lactobacillus reuteri was not better than placebo in controlling IBS symptoms in this study. However, considering the significant placebo effect in IBS patients, it may be necessary to conduct studies with larger numbers of participants to better assess the possible beneficial effects of Biogaia. [ABSTRACT FROM AUTHOR]
- Published
- 2013
12. Treatment of Gastro-Esophageal Reflux Disease May Improve Surgical Outcomes for Chronic Otitis Media.
- Author
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Karimi Yazdi, Alireza, Tajdini, Ardavan, Malekzadeh, Reza, Nasseri-Moghaddam, Siavosh, Mazlum, Maryam, Nokhbeh-Zaeem, Habibeh, Biazar, Parastoo, and Amiri, Mandana
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GASTROESOPHAGEAL reflux treatment ,CHI-squared test ,CHRONIC diseases ,EAR surgery ,OTITIS media ,HEALTH outcome assessment ,T-test (Statistics) ,RANDOMIZED controlled trials ,TREATMENT effectiveness ,DATA analysis software ,EVALUATION - Abstract
BACKGROUND This study has been designed to investigate the clinical association between gastro esophageal reflux disease (GERD) and chronic otitis media (COM) in adults and also the role of GERD treatment on the outcome of COM surgery. METHODS In a randomized clinical trial, 58 patients with COM who were candidates for surgery were evaluated for GERD and divided in two groups; GERD positive (case) and GERD negative (control) patients. The GERD positive patients were randomized to either receiving medical treatment for GERD or not prior to surgery. The surgical outcomes were assessed at 3 and 6 months after COM surgery in the three groups. RESULTS Fifty-eight (26 males) patients were enrolled. Forty-two (72.4%) of these had GERD according to a validated questionnaire. Three months after surgery auditory recovery in GERD negative patients was significantly higher [16(100%)] than those suffering from GERD [28 out of 42 (66.7%)],p=0.008. The figures remained similar at six months follow up as well (100 % vs. 72.5% in GERD negative and positive patients respectively, p=0.002). In the GERD-positive group, 8 of 18 (44.4%) patients who did not receive GERD treatment before tympanomastoidectomy recovered after three months whereas, while 20 of 24 (83.3%) patients who received GERD treatment recovered during this time (p≤.001 ). At six months 44.4% of non-treated GERD patients had auditory recovery as compared to 95.5 % of those treated for GERD(p<0.01). CONCLUSION Our data show that the effect of GERD on the outcome of COM surgery may be considerable. On the other hand, treating COM patients for GERD medically for two months before tympanoplasty improves the surgical outcomes. Therefore, we suggest that COM patients be evaluated for GERD before undergoing tympanoplasty and if GERD is present, they be treated medically for a couple of months before undergoing surgery. [ABSTRACT FROM AUTHOR]
- Published
- 2012
13. Inflammatory Bowel Disease.
- Author
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Nasseri-Moghaddam, Siavosh
- Subjects
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INFLAMMATORY bowel disease diagnosis , *INFLAMMATORY bowel disease treatment , *CROHN'S disease , *INFLAMMATORY bowel diseases , *ULCERATIVE colitis , *DECISION making in clinical medicine - Abstract
Inflammatory bowel disease (IBD) is the term used for a group of diseases with yet unknown etiology, prevalence of which is increasing almost everywhere in the world. The disease was almost non-existent four decades ago in the east, including the middle-east, while now a days it is seen more and more. In addition to the increasing prevalence, our knowledge about its pathogenesis, clinical course, diagnosis, and treatment has changed dramatically over the past couple of decades. This has changed our concept of this group of diseases, their diagnosis, treatment, and treatment goals. Considering the vast literature on the subject, it is timely to review major topics in IBD with a look on the regional progress and knowledge as well. This essay is aimed to cover this task. [ABSTRACT FROM AUTHOR]
- Published
- 2012
14. Characteristics of colorectal polyps and cancer; a retrospective review of colonoscopy data in iran.
- Author
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Delavari A, Mardan F, Salimzadeh H, Bishehsari F, Khosravi P, Khanehzad M, Nasseri-Moghaddam S, Merat S, Ansari R, Vahedi H, Shahbazkhani B, Saberifiroozi M, Sotoudeh M, and Malekzadeh R
- Abstract
BACKGROUND Early diagnosis and endoscopic resection of adenomatous polyps is the main approach for screening and prevention of colorectal cancer (CRC). We aimed to assess polyp detection rate (PDR) and to characterize demographic, clinical, and pathological features of colorectal polyps in an Iranian population. METHODS We retrospectively analyzed the data from 5427 colonoscopies performed during 2007-2012 at Masoud Clinic, the main endoscopy center associated with Sasan Alborz Biomedical Research Center, in Tehran, Iran. RESULTS Our sample included 2928 (54%) women and 2499 (46%) men, with the mean age of 48.3 years (SD=16.1). The most common reasons for colonoscopy included screening in 25.0%, and gastrointestinal bleeding in 15.2%. Cecal intubation was successful in 86% of patients. The quality of bowel preparation was fair to excellent in 78.1% (n=4235) of colonoscopies. Overall PDR was 42.0% (95% CI: 40.6-43.3). The PDR in men (51.1%, 95% CI: 49.1-53.1) was significantly higher than women (34.2%, 95% CI: 32.4-35.9, p<0.001). Polyps were more frequently observed in patients after the 6(th) decade of life (F=3.2; p=0.004). CRC was detected in 2.9% (73/2499) of men and 1.9% (57/2928) of women (p=0.02). The mean age for patients with cancer was significantly higher than that for individuals with polyps, 60.9 (SD=13.4) year vs. 56.9 (SD=13.7) year, respectively (p=0.001). Almost 82.8% of the lesions were precancerous with tubular type predominance (62.3%) followed by tubulo-villous (10.3%), villous (6.6%), and serrated (3.6%). Hyperplastic/inflammatory polyps comprised 17.2% of lesions. CONCLUSION Distal colon was more prone to develop polyps and cancer than proximal colon in our series. These findings provide a great infrastructure for next preventive programs and have implications for colorectal cancer screening at population-level.
- Published
- 2014
15. Probiotic vs. Placebo in Irritable Bowel Syndrome:A Randomized Controlled Trial.
- Author
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Amirimani B, Nikfam S, Albaji M, Vahedi S, Nasseri-Moghaddam S, Sharafkhah M, Ansari R, and Vahedi H
- Abstract
Background: This study assesses the potential effect of Lactobacillus reuteri as a single strain probiotic preparation (Biogaia®) on irritable bowel syndrome (IBS)., Methods: Patients diagnosed with IBS who fulfilled Rome III criteria and consented to participate in this study were randomized to receive either the probiotic or an identical placebo once daily for four weeks. Patients used a questionnaire to record any symptoms and adverse reactions over a one-week run-in period and during the final two weeks of intervention. For each group, we calculated the differences between mean scores of the variables and compared the results between groups., Results: Frequency of defecation increased in the Biogaia® group and decreased in the placebo group meaningfully. But There were no significant difference in the two groups in other terms of bloating, sense of urgency for defecation, abdominal pain, stool shape, quality of defecation, sense of incomplete evacuation, and treatment satisfaction., Conclusion: The frequency of defecation increased in the Biogaia® group and decreased in the placebo group, however this study did not classify patients according to diarrhea or constipated subgroups, the efficacy of this drug is not clear. Hence Lactobacillus reuteri was not better than placebo in controlling IBS symptoms in this study. However, considering the significant placebo effect in IBS patients, it may be necessary to conduct studies with larger numbers of participants to better assess the possible beneficial effects of Biogaia.
- Published
- 2013
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