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A novel on-chip integration of pressure plus 2-axis (X/Z) acceleration composite sensors for upgraded production of automobile tire pressure monitoring system (TPMS) is proposed, developed, and characterized. Herein, the X-axis accelerometer is with the cantilever beam-mass structure and is used for automatically identifying and positioning each of the four wheels. The IC-Foundry-Compatible low-cost batch fabrication technique of MIS (i.e., Micro-openings Inter-etch and Sealing) is employed to only fabricate the device from the front side of (111) silicon wafer, without double-sided micromachining, wafer bonding, complex Cavity-SOI (Silicon on Insulator) processing, and expensive SOI-wafer needed. Benefited from the single-wafer front-side fabrication technique on ordinary single-polished wafers, the fabricated composite TPMS sensor has the advantages of a small chip-size of 1.9 mm &times, 1.9 mm, low cross-talk interference, low-cost, and compatible process with IC-foundries. The fabricated pressure sensors, X-axis accelerometer and Z-axis accelerometer, show linear sensing outputs, with the sensitivities as about 0.102 mV/kPa, 0.132 mV/kPa, and 0.136 mV/kPa, respectively. Fabricated with the low-cost front-side MIS process, the fabricated composite TPMS sensors are promising in automotive electronics and volume production.