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2 results on '"Yonggang Nie"'

1. Multi-omics reveals the positive leverage of plant secondary metabolites on the gut microbiota in a non-model mammal

Author

Le Wang, Guangping Huang, Rong Hou, Dunwu Qi, Qi Wu, Yonggang Nie, Zhenqiang Zuo, Rui Ma, Wenliang Zhou, Yingjie Ma, Yibo Hu, Zhisong Yang, Li Yan, and Fuwen Wei

Subjects
PSMs, Flavonoids, Giant pandas, Metabolomics, Metagenomics, Microbial ecology, QR100-130
Abstract

Abstract Background Flavonoids are important plant secondary metabolites (PSMs) that have been widely used for their health-promoting effects. However, little is known about overall flavonoid metabolism and the interactive effects between flavonoids and the gut microbiota. The flavonoid-rich bamboo and the giant panda provide an ideal system to bridge this gap. Results Here, integrating metabolomic and metagenomic approaches, and in vitro culture experiment, we identified 97 flavonoids in bamboo and most of them have not been identified previously; the utilization of more than 70% flavonoid monomers was attributed to gut microbiota; the variation of flavonoid in bamboo leaves and shoots shaped the seasonal microbial fluctuation. The greater the flavonoid content in the diet was, the lower microbial diversity and virulence factor, but the more cellulose-degrading species. Conclusions Our study shows an unprecedented landscape of beneficial PSMs in a non-model mammal and reveals that PSMs remodel the gut microbiota conferring host adaptation to diet transition in an ecological context, providing a novel insight into host-microbe interaction. Video abstract

Published
2021
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2. Multi-omics reveals the positive leverage of plant secondary metabolites on the gut microbiota in a non-model mammal

Author

Wenliang Zhou, Li Yan, Yibo Hu, Le Wang, Fuwen Wei, Yingjie Ma, Guangping Huang, Dunwu Qi, Ma Rui, Rong Hou, Zhisong Yang, Zhenqiang Zuo, Yonggang Nie, and Qi Wu

Subjects
Microbiology (medical), Bamboo, Flavonoid, Zoology, Context (language use), Gut flora, Microbiology, Microbial ecology, Metabolomics, Animals, heterocyclic compounds, Flavonoids, chemistry.chemical_classification, biology, Giant pandas, Research, PSMs, QR100-130, fungi, food and beverages, biology.organism_classification, Diet, Gastrointestinal Microbiome, carbohydrates (lipids), chemistry, Metagenomics, Metagenome, Host adaptation, Ursidae
Abstract

Background Flavonoids are important plant secondary metabolites (PSMs) that have been widely used for their health-promoting effects. However, little is known about overall flavonoid metabolism and the interactive effects between flavonoids and the gut microbiota. The flavonoid-rich bamboo and the giant panda provide an ideal system to bridge this gap. Results Here, integrating metabolomic and metagenomic approaches, and in vitro culture experiment, we identified 97 flavonoids in bamboo and most of them have not been identified previously; the utilization of more than 70% flavonoid monomers was attributed to gut microbiota; the variation of flavonoid in bamboo leaves and shoots shaped the seasonal microbial fluctuation. The greater the flavonoid content in the diet was, the lower microbial diversity and virulence factor, but the more cellulose-degrading species. Conclusions Our study shows an unprecedented landscape of beneficial PSMs in a non-model mammal and reveals that PSMs remodel the gut microbiota conferring host adaptation to diet transition in an ecological context, providing a novel insight into host-microbe interaction.

Published
2021

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