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The activity of the QUTR transcription repressor protein in the quinic acid utilization pathway of Aspergillus nidulans nullifies the action of the QUTA activator protein. Genetic analyses suggest three mechanisms of action of the QUTR protein. The first indicates that high levels of QUTR protein result in the formation of another protein that interacts with QUTA protein to inactivate it. The second possibility is the production of a pool of organic molecules that inactivate QUTA and the third is an inactivating effect through a protein-protein interaction with the QUTA protein.