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Your search keyword '"Kumiko Kawamura"' showing total 3 results
Start Over Author "Kumiko Kawamura" Journal microbial drug resistance (larchmont, n.y.)
3 results on '"Kumiko Kawamura"'

1. Spread of

Author

Kumiko, Kawamura, Kazuki, Kitaoka, Kouji, Kimura, Jun-Ichi, Wachino, Takaaki, Kondo, Yoshitsugu, Iinuma, Nobuo, Murakami, Shuhei, Fujimoto, and Yoshichika, Arakawa

Subjects
DNA, Bacterial, Methicillin-Resistant Staphylococcus aureus, Cross Infection, Genotype, Virulence Factors, Bacterial Toxins, Exotoxins, Microbial Sensitivity Tests, Chromosomes, Bacterial, Staphylococcal Infections, Anti-Bacterial Agents, Methicillin, Asian People, Humans, Aged, Multilocus Sequence Typing
Abstract

We investigated the prevalence and molecular epidemiology of methicillin-resistant

Published
2019

2. Prevalence of CTX-M-Type Extended-Spectrum β-Lactamase-Producing

Author

Kumiko, Kawamura, Kengo, Hayashi, Nao, Matsuo, Kazuki, Kitaoka, Kouji, Kimura, Jun-Ichi, Wachino, Takaaki, Kondo, Yoshitsugu, Iinuma, Nobuo, Murakami, Shuhei, Fujimoto, and Yoshichika, Arakawa

Subjects
Aged, 80 and over, Male, Escherichia coli Proteins, Microbial Sensitivity Tests, Middle Aged, Long-Term Care, beta-Lactam Resistance, beta-Lactamases, Anti-Bacterial Agents, Feces, Japan, Escherichia coli, Prevalence, Humans, Female, Escherichia coli Infections, Aged, Plasmids
Abstract

We investigated the prevalence and characteristics of extended-spectrum β-lactamase (ESBL)-producing

Published
2018

3. First detection of fosfomycin resistance gene fosA3 in CTX-M-producing Escherichia coli isolates from healthy individuals in Japan

Author

Kunihiko Nakane, Yoshichika Arakawa, Jun-ichi Wachino, Kumiko Kawamura, and Natsumi Sato

Subjects
Microbiology (medical), Retroelements, Genetic Linkage, Immunology, Microbial Sensitivity Tests, Fosfomycin, Biology, medicine.disease_cause, Microbiology, beta-Lactamases, Plasmid, Japan, Genetic linkage, Drug Resistance, Multiple, Bacterial, medicine, Escherichia coli, Humans, Replicon, Gene, Escherichia coli Infections, Pharmacology, Genetics, biochemical phenomena, metabolism, and nutrition, Anti-Bacterial Agents, Healthy individuals, Carrier State, Mobile genetic elements, medicine.drug, Plasmids
Abstract

We examined the prevalence and mechanism of fosfomycin resistance in CTX-M-producing Escherichia coli isolates from healthy Japanese individuals. One hundred thirty-eight CTX-M-producing E. coli isolates were subjected to fosfomycin susceptibility testing. The presence of acquired fosfomycin resistance genes such as fosA, fosA3, and fosC2 was explored, and the transmissibility of fosfomycin resistance, replicon type of plasmid, and genetic environment of fosA3 were investigated. Eight isolates (5.8%) showed resistance to fosfomycin, five of which harbored fosA3, which was in genetic linkage with blaCTX-M. The replicon types of the five transferred fosA3-carrying plasmids were as follows: IncI1 (n=2), IncN (n=1), and IncFII (n=2). Each fosA3 gene was located close to the blaCTX-M gene and was flanked by IS26 elements. These genetic environments of fosA3 in E. coli from healthy individuals were quite similar to those observed in the clinical and veterinary settings. Our results indicate that fosA3 genes possibly inserted by small mobile genetic elements flanked by two IS26 elements have already spread throughout the plasmids along with the blaCTX-M genes of commensal E. coli colonizing in healthy Japanese people.

Published
2013

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