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Your search keyword '"Smyth, LJ"' showing total 2 results
Start Over Author "Smyth, LJ" Journal methods in molecular biology clifton n j
2 results on '"Smyth, LJ"'

1. Genetic Strategies to Understand Human Diabetic Nephropathy: In Silico Strategies for Molecular Data-Association Studies.

Author

Canadas-Garre M, Smyth LJ, Anderson K, Kerr K, and McKnight AJ

Subjects
Computational Biology instrumentation, Computers, Datasets as Topic, Genetic Predisposition to Disease, Genome-Wide Association Study methods, Humans, Polymorphism, Single Nucleotide, Risk Factors, Software, Computational Biology methods, Diabetic Nephropathies genetics, Meta-Analysis as Topic
Abstract

Multiple genetic strategies are available to help improve understanding of diabetic nephropathy. This chapter provides detailed methodology for a single-nucleotide polymorphism association study and meta-analysis, using a protocol suitable for targeted SNP or genome-wide association studies, to identify genetic risk factors for diabetic nephropathy.

Published
2020
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2. Genetic Strategies to Understand Human Diabetic Nephropathy: Wet-Lab Approaches.

Author

Smyth LJ, Kerr K, Duffy S, Kilner J, and McKnight AJ

Subjects
Case-Control Studies, Computational Biology, Cross-Sectional Studies, Diabetes Mellitus, Type 1 complications, Diabetes Mellitus, Type 1 pathology, Diabetes Mellitus, Type 1 urine, Diabetes Mellitus, Type 2 complications, Diabetes Mellitus, Type 2 pathology, Diabetes Mellitus, Type 2 urine, Diabetic Nephropathies diagnosis, Diabetic Nephropathies urine, Follow-Up Studies, Genetic Predisposition to Disease, Humans, Polymorphism, Single Nucleotide, Risk Factors, Diabetic Nephropathies genetics, Genetic Association Studies methods, High-Throughput Nucleotide Sequencing, Research Design
Abstract

Multiple genetic strategies are available to help improve understanding of diabetic nephropathy. This methods chapter provides an overview of phenotype considerations specific to diabetic nephropathy and biobank essentials, and provides detailed methodology for a common benchtop wet-lab approach (Ion Torrent semiconductor sequencing) including in silico genetic variant identification from next-generation sequencing data to identify genetic risk factors for diabetic nephropathy.

Published
2020
Full Text
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