1. Mapping Amyloid Regions in Gad m 1 with Peptide Arrays.
- Author
-
Sánchez R, Martínez J, Montoya L, Castellanos M, and Gasset M
- Subjects
- Animals, Fish Proteins chemistry, Protein Array Analysis, Protein Conformation, beta-Strand, Gadus morhua metabolism, Parvalbumins chemistry, Peptide Mapping methods
- Abstract
Amyloid formation is basically featured by a protein-protein interaction in which the reacting regions are the segments assembling into cross β-sheets. To identify these segments both theoretical and experimental tools have been developed. Here, we focus on the use of peptide arrays to probe the binding of several amyloid-specific probes such as the OC and A11 anti-amyloid conformation-selective antibodies and of monomers and preformed fibrils. These arrays use libraries containing partly overlapping peptides derived from the sequence of Gad m 1, the major allergen from Atlantic cod, which forms amyloids under gastrointestinal relevant conditions.
- Published
- 2018
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