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Start Over "Frank Heuts" Topic immune system Journal methods in molecular biology (clifton, n.j.)
1 results on '"Frank Heuts"'

1. Mice with Reconstituted Human Immune System Components as a Tool to Study Immune Cell Interactions in EBV Infection

Author

Frank, Heuts and Noemi, Nagy

Subjects
Gene Expression Regulation, Viral, Mice, Knockout, B-Lymphocytes, Epstein-Barr Virus Infections, Herpesvirus 4, Human, Transplantation Chimera, Genes, Viral, T-Lymphocytes, Cell Communication, Virus Replication, Immunophenotyping, Virus Latency, Disease Models, Animal, Mice, Mice, Inbred NOD, Immune System, Host-Pathogen Interactions, Animals, Humans, Lymph Nodes, Biomarkers, Spleen
Abstract

Recent developments in mouse models that harbor part of a human immune system have proved extremely valuable to study the in vivo immune response to human specific pathogens such as Epstein-Barr virus. Over the last decades, advances in immunodeficient mouse strains that can be used as recipients for human immune cells have greatly enhanced the use of these models. Here, we describe the generation of mice with reconstituted human immune system (HIS mice) using immunocompromised mice transplanted with human CD34

Published
2016

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