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Groundwater recharge depends generally on precipitation. In this study, a geographical information system (GIS) procedure was applied to assess the climate change effect on groundwater recharge in the Grand Est region of France. The analysis comprises high‐resolution climate models that reflect the long‐term climatological regime. The hydrological properties include aquifers, land‐cover and terrain morphology data, which were used to develop the potential infiltration map of the study area. Two parameters, the De Martonne aridity index and effective precipitation, were combined into a 5 × 5 matrix to assess the climate change effect on groundwater recharge during the past (1990s), present (2020s) and future (2050s) periods. The present and future intense aridization and the depletion of the effective precipitation (< 650 mm) reveal the negative effects of climate change on aquifers' recharge in the Grand Est region. The areas with high and very high climate effects will increase in the 2020s and 2050s. These areas extend mainly in the western, north‐central and northeastern parts of the region occupying the Rhine, Aube and Marne valleys. The medium effect could be found in the central, southern and northwestern parts, while the low impact on groundwater recharge was verified in the northwestern and southeastern parts of the region. The area with low effects of climate change extends mostly in the Vosges and Ardennes mountains. These findings contribute to the long‐term hydrogeological studies in the Grand Est region. [ABSTRACT FROM AUTHOR]