1. Effect of hypoxia on plasma immunoreactive endothelin-1 concentration in anesthetized rats
- Author
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Naotsugu Kurihara, Takeshi Horio, Koh-ichi Murakawa, Tadanao Takeda, Masakazu Kohno, Kenichi Yasunari, Koji Yokokawa, and Hiroshi Fujiwara
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Male ,medicine.medical_specialty ,Time Factors ,Partial Pressure ,Endocrinology, Diabetes and Metabolism ,Radioimmunoassay ,Hemodynamics ,Endocrinology ,Internal medicine ,Heart rate ,medicine ,Animals ,Anesthesia ,business.industry ,Endothelins ,Osmolar Concentration ,Rats, Inbred Strains ,Carbon Dioxide ,Hydrogen-Ion Concentration ,Hypoxia (medical) ,Endothelin 1 ,Rats ,Oxygen ,Mean blood pressure ,Blood pressure ,Arterial blood ,medicine.symptom ,Endothelin receptor ,business - Abstract
The present study was designed to examine the possible influence of hypoxia on plasma immunoreactive (ir) endothelin-1 concentrations in anesthetized rats. Plasma ir-endothelin-1 concentration, blood pressure, heart rate, and arterial gas levels were measured 1 and 2 hours after exposure to normoxic (20% O2), mildly hypoxic (16% O2), and severely hypoxic (12% O2) gas. Mean blood pressure and heart rate were significantly decreased and the plasma ir-endothelin-1 concentration was significantly increased in severely hypoxic rats after both 1 and 2 hours. In mildly hypoxic rats, the plasma ir-endothelin-1 concentration was also increased, but this value was not statistically significant. The plasma ir-endothelin-1 concentration was inversely correlated with arterial blood PO2 in the three study groups (normoxic, mildly hypoxic, and severely hypoxic rats) after 1 hour (n = 18, r = -.74, P less than .01), and after 2 hours (n = 18, r = .71, P less than .01). Our results indicate that severe hypoxia increased the plasma ir-endothelin-1 level in anesthetized rats. The observed increase in plasma ir-endothelin-1 level may represent a compensatory mechanism against the blood pressure reduction associated with severe hypoxia.
- Published
- 1991
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