1. Observations on the renal metabolism of protein in experimental and clinical nephrotic syndromes
- Author
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Thomas Findley, Hy C. Sussman, and Barbara Fowler
- Subjects
medicine.medical_specialty ,Nephrotic Syndrome ,Cirrhosis ,Nitrogen ,Endocrinology, Diabetes and Metabolism ,Kidney ,Glomerulonephritis ,Endocrinology ,Internal medicine ,Methods ,medicine ,Animals ,Humans ,Amines ,Amino Acids ,Serum Albumin, Radio-Iodinated ,Serum Albumin ,Chemistry ,Albumin ,Proteins ,Nucleosides ,Venous Plasma ,Metabolism ,medicine.disease ,Rats ,Peripheral ,Proteinuria ,Kidney Tubules ,medicine.anatomical_structure ,Hematocrit ,Liver ,Kidney Diseases ,Specific activity ,Peptides - Abstract
Renal and peripheral arteriovenous differences (A-V/A) of albumin, peptide-N and α-amino-N were compared in normal and aminonucleoside treated rats. Significant accumulations of peptide-N were demonstrated in the renal venous plasma of nephrotic animals which was supported by similar results obtained when kidney and liver slices were incubated with RISA. Specific activity ratios (F/P) were determined for the TCA soluble (F) and precipitable (P) fractions of plasma from 5 normal persons, 8 patients with idiopathic nephrotic syndrome or membranous glomerulonephritis and 3 with cirrhosis. A significant difference was obtained between the normal and hypoalbuminemic subjects attributed to the greater accumulation of radioactivity in the protein-free filtrate in the latter group. These data suggest accelerated proteolytic activity in experimental and cliincal nephrotic syndromes but do not indicate that other abnormalities of albumin metabolism are not operative or that the defect is specific for renal disease.
- Published
- 1968
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