1. A prevalent caveolin-1 gene variant is associated with the metabolic syndrome in Caucasians and Hispanics
- Author
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Baudrand, Rene, Goodarzi, Mark O, Vaidya, Anand, Underwood, Patricia C, Williams, Jonathan S, Jeunemaitre, Xavier, Hopkins, Paul N, Brown, Nancy, Raby, Benjamin A, Lasky-Su, Jessica, Adler, Gail K, Cui, Jinrui, Guo, Xiuqing, Taylor, Kent D, Chen, Yii-Der I, Xiang, Anny, Raffel, Leslie J, Buchanan, Thomas A, Rotter, Jerome I, Williams, Gordon H, and Pojoga, Luminita H
- Subjects
Nutrition ,Obesity ,Diabetes ,Clinical Research ,Cardiovascular ,Genetics ,2.1 Biological and endogenous factors ,Aetiology ,Metabolic and endocrine ,Adult ,Caveolin 1 ,Cohort Studies ,Female ,Genotype ,Hispanic or Latino ,Humans ,Male ,Metabolic Syndrome ,Middle Aged ,Whites ,Metabolic syndrome ,Insulin resistance ,Cardiovascular risk ,White People ,Clinical Sciences ,Endocrinology & Metabolism - Abstract
Context and objectiveWe examined whether a prevalent caveolin-1 gene (CAV1) variant, previously related to insulin resistance, is associated with metabolic syndrome (MetS).Patients and methodsWe included subjects genotyped for the CAV1 variant rs926198 from two cohorts: 735 Caucasians from the HyperPATH multicenter study, and 810 Hispanic participants from the HTN-IR cohort.ResultsMinor allele carriers from HyperPATH cohort (57% of subjects) had higher Framingham risk scores, higher odds of diabetes (10.7% vs 5.7%, p=0.016), insulin resistance (44.3% vs 35.1%, p=0.022), low HDL (49.3% vs 39.6%, p=0.018) and MetS (33% vs 20.5%, p
- Published
- 2015