1. Expression analysis of apoptosis-related genes in bladder cancer patients
- Author
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Vahid Kholghi Oskooei, Niusha Samadaian, Leila Nekoohesh, Tamouchin Moharrami, Mandana Afsharpad, Soudeh Ghafouri-Fard, Mohammad Hossein Modarressi, and Fatemeh Yazarlou
- Subjects
0301 basic medicine ,Bladder cancer ,business.industry ,Urinary system ,Cell ,Cancer ,Urine ,medicine.disease ,BAG3 ,03 medical and health sciences ,030104 developmental biology ,medicine.anatomical_structure ,Expression analysis ,Genetics ,Cancer research ,medicine ,business ,Gene ,Genetics (clinical) - Abstract
Background Bladder cancer (BC) is a frequent cancer with high morbidity and mortality. Method We assessed expression of NMP22, BAG3, BCL2 and BAX in BC samples, adjacent non-neoplastic tissues (ANNTs), urinary cell pellets (UCP) of the same patients and non-malignant conditions (NM). Results NMP22 was up-regulated in tumoral tissues compared with ANNTs and in UCP of BC patients compared with UCP of NM. BCL2 and BAX were down-regulated in BC tissues compared with ANNTs. BAG3 and BAX were down-regulated in UCP of BC compared with NM. The combination of all four genes had 100% sensitivity and specificity for detection of BC in urine. Conclusion Expression analysis of these genes in tumor or urine is a tool for detection of BC.
- Published
- 2018
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