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The work was aimed to find new screeding parameters (biomarkers) for evaluation of health state of workers engaged into enterprises with hazardous work conditions, as exemplified by "Maradykovskyi" object of chemical weapons extinction. Analysis of 27 serum cytokines was conducted in donors and the object personnel with various work conditions. Findings are statistically significant increase of serum eotaxin in the personnel of "dirty" zone, who are regularly exposed to toxic agents in individual filter protective means over the working day. For screening detection of health disorders in the object personnel, the authors suggested new complex biomarker--ratio Eotaxin* IFNγ/TNFα that demonstrates 67.9% sensitivity and 87.5% specificity in differentiating the "dirty" zone personnel and other staffers.

The article covers problems of biochemical methods assessing organophosphorus toxic compounds in objects of chemical weapons extinction. The authors present results of works developing new, more specific and selective biochemical methods.

The article presents results of life quality assessment and subjective evaluation data on health state, used for prenosologic evaluation of health state in residents of protective measures area near objects of storage and destruction of chemical weapons. Considering specific features of residence near potentially dangerous objects, the authors conducted qualitative evaluation of satisfaction with various life facets, with taking into account the objects specificity, established correlation between life quality and self-evaluation of health with factors influencing public health state.

The results of health assessment of the population living and working in the protective actions zone by the evidence obtained during general and special meadical examinations are summarized.

The authors studied functional state before and after the working shift in workers at objects for chemical weapons destruction, analyzed changes in central and peripheral hemodynamics parameters, vegetative regulation of heart rhythm, stabilographic and psychophysiologic values.

The authors summarized study results on chronic effects caused by products of leaching from bituminous-salt masses obtained through destruction of sarin, soman and RVX. State of experimental rats was evaluated with integral informative tests (physiologic, biochemical, hematologic and morphologic) presenting changes in objective health parameters and revealing every disorder in organs and systems functioning.

The authors designed a set of instructions and methodic documents and universal methodology for sanitary and hygienic follow-up in establishments running chemical weapons demolishment. Those instructions and methodology are aimed to safety of workers and general population.

Chemical weapons elimination on Russian Federation territory positions some problems that should be solved to prevent harm for public health and environment in Russia. The author specified corresponding methodic recommendations.