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The purpose of our study was prediction of ground water contamination with fungicides of different chemical classes in soil-climatic conditions of Ukraine and other European countries and hygienic assessment of their harmful effects on human health. The materials contain field experiments results and literature data. It was established that according to stability in the soil, substance of a new chemical class of triazolopyrimidines – ametoctradin relates to the 4-th hazard class (low hazardous substances), triazoles belong to the 2-nd class (hazardous substances) and pyrimidines and morpholines – to the 3-d class (moderately hazardous substances). It was also found that ametoctradin which relates to the 4-th hazard class according to integral index of danger is the least dangerous, when released into the drinking water.