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The authors have presented their observations in 108 pathologically processed cases of primary hepatic carcinoma (PHC). The material includes the period from 1962 to 1990. The most frequent form of PHC was hepatocellular (67.5%), the cholangiocellular (29.5%) and rarest, the mixed hepato-cholangiocellular form (2.9%). X-ray diagnostics were applied (celiacography, arteriography), laparoscopy, ultrasonography, aimed and blind aspirational biopsy, and laboratory examinations (alkaline phosphatase, transaminases, bilirubin, gamma-CT and so on). Somewhat more attention is given to the problem of HBV infection as the cause of primary hepatic carcinoma development. Pre-existing liver tissue diseases are also pleaded for (chronic aggressive hepatitis, hepatic cirrhosis, ect.). Beside the many diagnostic procedures, the diagnosis of primary hepatic carcinoma is usually established too late, and the therapy still remains unsatisfactory.

The paper presents the results of a comparative investigation of CA-50 and CA 72-4 in the serum and effusions of the control group and a group of patients with various localizations of malignant tumors. The diagnostic applicability of CA-50 in the serum is limited by a substantial extent of falsely positive results, which is not the case with CA 72-4. Malignant cells make a more intensive release of CA 72-4 into effusions than into the blood, and the situation with CA-50 is reverse. It has been established that CA-50 in the serum and that CA 72-4 in effusions are complementary parameters. Markers in effusions have more favorable diagnostic characteristics in relation to serum. Although CA 72-4 is of a more superior diagnostic reliability, the examining of both markers is of help in the differentiation of benign peritoneal and pleural effusions from the malignant ones. The persistence of these markers in body fluids does not indicate the primary origin of malignant tumors.

The author brings out a brief survey of the development of Subotica as a city, and the development and achievements in it on a social and cultural scale during the 18th and 19th century. He states, that in the last decades of the past century, Subotica was a very strong economic and cultural center of this part of Vojvodina. Such a surrounding was offered, and afterwards it was decided upon, to organize an elite, professional and scientific manifestation--The Annual Meeting of Physicians and Naturalists of that--time Hungary. Here is an account of this First Scientific Meeting in Subotica, which was just the 30th Jubilee Meeting of the Physicians and Naturalists of Hungary. About 100 scientists took part in the work of this meeting, and 74 reports were presented. The holding of such a meeting in Subotica is, no doubt, an important moment in the cultural life of Subotica, and an especially important date in the development of the health service and science within it.