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We have performed a complex study of low-intensity magnet/laser effects upon main effector functions of neutrophils in females suffering with chlamydial infection. A dysfunction of neutrophil granulocytes was revealed in this group of patients. First of all, it manifested as decreased number of bactericidal and phagocytic activity and lower rates of phagocytosis. It was found out that the proportion of active intracellular forms of oxygen was considerably decreased in patients, as compared to healthy subjects. A combined treatment by low-intensity laser irradiation and magnetic fields caused elimination of the revealed neutrophilic dysfunction.

The aim of the work was to evaluate clinical features of purulent wounds trend and functional activity of local wound phagocytes in the patients with odontogenic phlegmones in the course of local treatment with Ronkoleukin. A randomized clinical study was performed which included sixty-five patients with odontogenic phlegmones. Their age ranged from 18 to 74 years old. The group was divided in two parts, i.e., patients of a comparison group (n = 33) receiving a conventional combined drug therapy, and the persons from study group (n = 32) who were subject to local immunotherapy with Ronkoleukin, applied along with conventional therapy. It was established that the local therapy with Ronkoleikin exerts distinct positive effects, i.e., increase in wound-located lymphocytes and macrophages, acceleration of phasic dynamics of inflammatory events, augmentation of an lysosomal luminescence index (2.3-fold), enhancement of phagocytosis intensity in wound neutrophiles and macrophages (1.9-2-fold), strengthening the reserve abilities of wound neutrophils (1.3-fold). These effects create favorable conditions for elimination of pathogen and optimal healing of purulent wounds in the patients with odontogenic phlegmones.

Characteristics of CD34+ cells mobilization were studied in children suffering with various diseases, like as their dependence on type and extent of inflammatory response. It was revealed that the children with signs of systemic inflammatory response syndrome exhibit a significant increase of absolute content and percentage of circulating CD34+ cells, whereas children with frequent infections, and with clinical signs of allergy during recurrence of their chronic allergic disease showed a significant decrease in CD34+ cell percentage. Meanwhile, children with allergoses, and those with common recurrent infectious states did not reveal any deviations in CD34+ cells from normal values.

The aim of the present work was to evaluate the contents of some lymphocyte sub-populations in peripheral blood of the children with tumors of hematopoietic and lymphoid tissues, depending on infectious complication of cytostatic therapy and neutropenia. In all children undergoing cytostatic therapy for acute lympho-blastic leukemia and non-B cell non-Hodgkinґs lymphomas, we found significant decrease in the numbers of CD95 lymphocytes, absolute amounts of natural killer cells (CD16, CD56-lymphocytes) and activated lymphocytes (СD11b, HLA-DR-cells), irrespective of neutrophile numbers in their blood and infectious complications. However, absolute number of CD25- lymphocytes was significantly decreased in the children with neutropenia. Relative contents of CD16, CD56, СD11b, HLA-DR, CD25-lymphocytes did not significantly differ from those in healthy children, or they were found to be significantly increased.

Study results of vaginal secretion cytokine system in 25 patients with urogenital trichomoniasis are presented. Concentration of interleukins:IL-1α, IL-1β, RAIL-1, TNFa, IL-8, IFN-γ has been performed. The character of pro-inflammatory cytokines changes in the local immunity system in females with urogenital trichomoniasis has been studied in comparison with these values in healthy females. It has been established that infected females have increased levels of IL-1α, IL-1β, RAIL-1, TNFα, IL-8, while IFN-γ concentration is decreased. The obtained results enable to get a deeper insight into the cytokine-mediated reactions in the local immunity system of genital tracts in case of trichomoniasis.