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Your search keyword '"Zhi-Fan Zeng"' showing total 4 results
Start Over Author "Zhi-Fan Zeng" Journal medicine
4 results on '"Zhi-Fan Zeng"'

1. Pathological Assessment of the AJCC Tumor Regression Grading System After Preoperative Chemoradiotherapy for Chinese Locally Advanced Rectal Cancer

Author

Yuanhong Gao, Weiwei Xiao, Kai-Yun You, Pu-Yun OuYang, Zhizhong Pan, Huizhong Zhang, Zhi-Fan Zeng, Lu-Ning Zhang, Rui-Hua Xu, Pei-Rong Ding, and Shaoyan Xi

Subjects
Adult, Male, medicine.medical_specialty, Colorectal cancer, Pathological staging, Observational Study, Preoperative care, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Asian People, Internal medicine, Preoperative Care, medicine, Humans, Pathological, Survival analysis, Aged, Neoplasm Staging, Retrospective Studies, Proportional hazards model, business.industry, Rectal Neoplasms, Remission Induction, Retrospective cohort study, General Medicine, Chemoradiotherapy, Middle Aged, medicine.disease, Prognosis, Survival Analysis, Surgery, Treatment Outcome, 030220 oncology & carcinogenesis, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, 030211 gastroenterology & hepatology, Female, Neoplasm Grading, business, Follow-Up Studies, Research Article
Abstract

Supplemental Digital Content is available in the text, We used American Joint Committee on Cancer (AJCC) Staging Manual system to assess the prognostic significance of tumor regression grading (TRG) for locally advanced rectal cancer (LARC) (T3/4 or N+) patients who were treated with preoperative chemoradiotherapy (CRT). The 4 AJCC-TRG classifications were evaluated on surgical specimens from 295 LARC patients receiving CRT. Overall survival (OS), disease-free survival (DFS), local recurrence-free survival (LRFS), and distant metastasis-free survival (DMFS) were estimated using Kaplan–Meier method and Cox regression model. Classifications of TRG 0, 1, 2, and 3 were found in 27.5%, 19.3%, 45.7%, and 7.5% of the resected specimens, respectively. Three-year OS was 95.5% for TRG0, 91.5% for TRG1, 84.8% for TRG2, and 85.7% for TRG3 (P = 0.035). Three-year DFS was 89.0% for TRG0, 74.4% for TRG1, 70.9% for TRG2, and 62% for TRG3 (P = 0.018). By multivariate analysis, AJCC-TRG (P = 0.033), residual lymph node metastasis (ypN+) (P

Published
2016

2. Elevated CA19-9 as the Most Significant Prognostic Factor in Locally Advanced Rectal Cancer Following Neoadjuvant Chemoradiotherapy

Author

Xin Yu, Yuanhong Gao, Rui-Hua Xu, Zhi Fan Zeng, Kai Yun You, Pu Yun OuYang, Wei Wei Xiao, and Lu Ning Zhang

Subjects
Oncology, Male, medicine.medical_specialty, endocrine system diseases, CA-19-9 Antigen, Colorectal cancer, medicine.medical_treatment, Observational Study, Disease-Free Survival, Internal medicine, medicine, Carcinoma, Humans, Survival rate, Retrospective Studies, Univariate analysis, Proportional hazards model, business.industry, Rectal Neoplasms, General Medicine, Chemoradiotherapy, Adjuvant, Middle Aged, medicine.disease, Prognosis, digestive system diseases, Survival Rate, CA19-9, Female, Neoplasm Recurrence, Local, business, Adjuvant, Chemoradiotherapy, Research Article
Abstract

It remains controversial regarding the prognostic significance of carbohydrate antigen 19-9 (CA19-9) for locally advanced rectal cancer (LARC) (T3–4/N+) patients with neoadjuvant chemoradiotherapy (neo-CRT). And it is unknown whether CA19-9 can identify patients who may benefit from adjuvant chemotherapy. Overall, 303 LARC patients with neo-CRT between 2004 and 2010 were recruited. Overall survival (OS), disease-free survival (DFS), distant metastasis-free survival (DMFS), and local recurrence-free survival across pretreatment CA19-9 were estimated by Kaplan–Meier method and Cox regression model. In univariate analysis, elevated CA19-9 (>35 U/mL) was significantly correlated with poor OS (P = 0.003), DFS (P = 0.001), and DMFS (P = 0.039). Adjusting for the known covariates, CA19-9 was significantly associated with OS (HR = 1.86, 95% CI 1.03–3.34, P = 0.039) and DFS (HR = 1.74, 95% CI 1.08–2.80, P = 0.024). In the elevated CA19-9 subgroup, patients with adjuvant chemotherapy got much better OS (P 5 ng/mL) got the worst OS (P = 0.021) and DFS (P = 0.006), and significantly benefited from adjuvant chemotherapy in OS (P

Published
2015

3. Pathological Assessment of the AJCC Tumor Regression Grading System After Preoperative Chemoradiotherapy for Chinese Locally Advanced Rectal Cancer.

Author

Lu-Ning Zhang, Wei-Wei Xiao, Shao-Yan Xi, Pu-Yun OuYang, Kai-Yun You, Zhi-Fan Zeng, Pei-Rong Ding, Hui-Zhong Zhang, Zhi-Zhong Pan, Rui-Hua Xu, Yuan-Hong Gao, Zhang, Lu-Ning, Xiao, Wei-Wei, Xi, Shao-Yan, OuYang, Pu-Yun, You, Kai-Yun, Zeng, Zhi-Fan, Ding, Pei-Rong, Zhang, Hui-Zhong, and Pan, Zhi-Zhong

Published
2016
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