1. Absence of association between pretransplant serum soluble programmed death protein-1 level and prognosis following living donor liver transplantation in patients with hepatocellular carcinoma
- Author
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Deok-Bog Moon, Kyungjin Lee, Sung-Gyu Lee, Gi-Won Song, Eunyoung Tak, Yun Kyu Kim, Chul-Soo Ahn, Shin Hwang, Yohan Park, Young-In Yoon, Gil-Chun Park, Byeong-Gon Na, Hunji Yang, Ki-Hun Kim, Tae-Yong Ha, and Dong-Hwan Jung
- Subjects
Adult ,Male ,medicine.medical_specialty ,recurrence ,Carcinoma, Hepatocellular ,Multivariate analysis ,medicine.medical_treatment ,Programmed Cell Death 1 Receptor ,Observational Study ,Liver transplantation ,Milan criteria ,Gastroenterology ,Disease-Free Survival ,03 medical and health sciences ,0302 clinical medicine ,Predictive Value of Tests ,Reference Values ,Internal medicine ,Living Donors ,medicine ,Carcinoma ,Humans ,030212 general & internal medicine ,immune checkpoint ,Retrospective Studies ,tumor biology ,business.industry ,Liver Neoplasms ,Retrospective cohort study ,hepatocellular carcinoma ,General Medicine ,Middle Aged ,Prognosis ,medicine.disease ,Liver Transplantation ,Treatment Outcome ,030220 oncology & carcinogenesis ,Predictive value of tests ,Hepatocellular carcinoma ,Multivariate Analysis ,Preoperative Period ,Cohort ,Female ,business ,Research Article - Abstract
Programmed death protein 1 (PD-1) pathway is one of the most critical mechanisms in tumor biology of hepatocellular carcinoma (HCC). The study aimed to assess the prognostic influence of pretransplant serum soluble PD-1 (sPD-1) in patients undergoing liver transplantation for treatment of HCC. Data from 229 patients with HCC who underwent living donor liver transplantation between January 2010 and December 2015 were retrospectively evaluated. Stored serum samples were used to measure sPD-1 concentrations. Overall survival (OS) and disease-free survival (DFS) rates were 94.3% and 74.5% at 1 year; 78.2% and 59.2% at 3 years; and 75.4% and 55.5% at 5 years, respectively. Prognostic analysis using pretransplant serum sPD-1 with a cut-off of 93.6 μg/mL (median value of the study cohort) did not have significant prognostic influence on OS (P = .69) and DFS (P = .26). Prognostic analysis using sPD-1 with a cut-off of 300 μg/mL showed similar OS (P = .46) and marginally lower DFS (P = .070). Combination of Milan criteria and sPD-1 with a cutoff of 300 μg/mL showed similar outcomes of OS and DFS in patients within and beyond Milan criteria. Multivariate analysis revealed that only Milan criteria was an independent prognostic for OS and DFS, but pretransplant sPD1 with a cut-off of 300 μg/mL did not become a prognostic factor. The results of this study demonstrate that pretransplant serum sPD-1 did not show significant influences on post-transplant outcomes in patients with HCC. Further large-scale, multicenter studies are necessary to clarify the role of serum sPD-1 in liver transplantation recipients.
- Published
- 2021