1. Natural Transmission Model for Severe Fever With Thrombocytopenia Syndrome Bunyavirus in Villages of Hubei Province, China
- Author
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Xuesen Xing, Xuhua Guan, Li Liu, Jianbo Zhan, Hongbo Jiang, Guoming Li, Jinfeng Xiong, Liangfei Tan, Junqiang Xu, Yongzhong Jiang, Xuan Yao, Faxian Zhan, and Shaofa Nie
- Subjects
Male ,Phlebovirus ,0301 basic medicine ,China ,Veterinary medicine ,Disease reservoir ,030231 tropical medicine ,Prevalence ,Observational Study ,Tick ,Antibodies, Viral ,Bunyaviridae Infections ,Models, Biological ,03 medical and health sciences ,Ticks ,0302 clinical medicine ,Blood serum ,Risk Factors ,Animals ,Humans ,Medicine ,Seroprevalence ,Disease Reservoirs ,biology ,business.industry ,Goats ,General Medicine ,Middle Aged ,biology.organism_classification ,medicine.disease ,Severe fever with thrombocytopenia syndrome ,Cross-Sectional Studies ,030104 developmental biology ,RNA, Viral ,Arachnid Vectors ,Cattle ,Female ,Haemaphysalis longicornis ,business ,Research Article - Abstract
Severe fever with thrombocytopenia syndrome (SFTS), an emerging high-fatality infectious disease, is caused by a novel bunyavirus. However, a clear natural transmission model has not yet been established. We conducted a cross-sectional study with in-depth investigation of villages to systematically understand the transmission and risk factors among humans, host animals, and vectors. Village residents were interviewed using standardized questionnaires, in which there were confirmed cases of new infections, between August 2012 and May 2013. Serum samples from all villagers and animals, as well as tick specimens, were collected for qRT-PCR and antibody testing. The seropositivity rate among villagers was 8.4% (35/419), which was lower than that among domesticated animals (54.0%, 27/50; χ2 = 81.1, P
- Published
- 2016