1. A research on the protein expression of p53, p16, and MDM2 in endometriosis
- Author
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Qian-Jin Fang, Lin Sang, and Xing-Bo Zhao
- Subjects
endometriosis ,Adult ,Endometriosis ,Observational Study ,Apoptosis ,Protein expression ,Pathogenesis ,Andrology ,03 medical and health sciences ,Endometrium ,0302 clinical medicine ,Follicular phase ,Medicine ,Humans ,030212 general & internal medicine ,p53 protein ,Cyclin-Dependent Kinase Inhibitor p16 ,biology ,business.industry ,MDM2 protein ,Proto-Oncogene Proteins c-mdm2 ,General Medicine ,Middle Aged ,medicine.disease ,female genital diseases and pregnancy complications ,Early Diagnosis ,p16 protein ,030220 oncology & carcinogenesis ,Ovarian Endometriosis ,biology.protein ,Immunohistochemistry ,Mdm2 ,Female ,Tumor Suppressor Protein p53 ,business ,Research Article - Abstract
This study aims to examine the expression of p53, p16, and murine double minute 2 (MDM2) protein in normal endometrium and endometriosis, in order to discuss the role of p53, p16, and MDM2 protein and apoptosis in the pathogenesis and development of endometriosis, and provide a theoretical basis for clinical diagnosis and treatment. The immunohistochemical streptavidin-biotin peroxidase method was used to detect the expression of p53, p16, and MDM2 in tissue samples obtained from 30 women with pathologically confirmed ovarian endometriosis and 29 women with pathologically confirmed normal endometrium. The relationship between p53, p16, and MDM2 expression and apoptosis was analyzed. In normal endometrium, the positive rate of p53 in the secretory phase was higher than that in the proliferative phase (P .05). As important apoptosis regulatory genes, p53, p16, and MDM2 might be involved in the pathogenesis and development of endometriosis.
- Published
- 2019