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45. Different dose of heparin in preventing radial artery occlusion after transradial coronary angiography

Author

Li, Fengde, Zhao, Ling, Pang, Yanlei, Zhang, Huijing, Li, Yong, and Zheng, Qun

Subjects
medicine.medical_specialty, Heart disease, business.industry, Perforation (oil well), General Medicine, medicine.disease, law.invention, 03 medical and health sciences, Pseudoaneurysm, Stenosis, 0302 clinical medicine, Randomized controlled trial, law, 030220 oncology & carcinogenesis, Internal medicine, Meta-analysis, medicine.artery, Occlusion, Medicine and Health Sciences, medicine, Cardiology, 030212 general & internal medicine, Radial artery, business
Abstract

Background When atherosclerosis occurs in the coronary artery, resulting in stenosis, occlusion, or spasm of the coronary artery, the supply of blood and oxygen to the myocardium will be reduced or even unavailable, resulting in myocardial necrosis and heart pain, chest tightness, dyspnea and other symptoms caused by myocardial necrosis are collectively referred to as coronary atherosclerotic heart disease. Coronary angiography can not only understand the degree of coronary artery damage, but also estimate the prognosis of coronary artery stenting, which provides a reliable reference for clinical treatment. Transradial coronary angiography (TCA) has the advantages of high success rate, small trauma, less complications, no bed rest, reduce hospital stay and other superiority, which accepted and used by physicians. Although the success rate of surgery is high, the postoperative complications will still affect the effect of surgery and the prognosis of patients. The main manifestations are radial artery occlusion (RAO), forearm hematoma formation, pseudoaneurysm formation, periosteal compartment syndrome, radial artery perforation, etc. Among the many ways to prevent RAO, anticoagulant therapy with common heparin is one of them, but the dosage of heparin is not clear. Therefore, we decided to use systematic evaluation to evaluate the clinical effectiveness and safety of different dose of heparin in preventing of RAO, and to provide clinical basis for the early prevention and treatment of RAO. Methods Two reviewers independently searched PubMed, Embase, the Cochrance Library, Web of Science, Medline, CBM Disc, CNKI, and WANFANG Data to find the eligible research. The retrieval about the randomized controlled trials of different dose of heparin in preventing the occurrence of RAO after TCA in recent years. The retrieval time is set between January 1990 and June 2020. The retrieval language is Chinese/English. Two researchers independently searched, managed and screened the literature through the search terms. When the 2 parties have inconsistent opinions on the inclusion or not of certain literature, the literature will be referred to the third researcher for discussion and decision. The included studies are conducted bias risk assessment through bias risk assessment tool, which based on Cochrane Handbook 5.0. The extracted data uses RevMan5.3 software for statistical processing. Results The research results of this systematic review will be published in peer-reviewed medical-related academic journals. Conclusion This study adopts the Meta-analysis method and expands the sample size, which will give high-quality evidence-based medicine evidence on the clinical effectiveness and safety of different dose of heparin in preventing the occurrence of RAO. Trial registration number OSF, DOI 10.17605/OSF.IO/CPXJ3.

Published
2020
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46. Patients with mild paraquat poisoning treated with prolonged low-dose methylprednisolone have better lung function

Author

Gao, Jie, Cao, Zongxun, Feng, Shunyi, Song, Yangying, Bai, Wenjing, Zhao, Shumin, Zhang, Suli, and Li, Yong

Subjects
Adult, Male, Paraquat, Pulmonary Fibrosis, Observational Study, lung function, Leukopenia, Methylprednisolone, Drug Administration Schedule, Forced Expiratory Volume, Humans, Female, Glucocorticoids, Research Article, Retrospective Studies
Abstract

Lung dysfunction is an important characteristic of injury induced by paraquat (PQ). This study aimed to evaluate the effects of prolonged low-dose methylprednisolone (MP) treatment on lung function in patients with mild PQ poisoning. We analyzed the results of lung function testing in all patients with mild PQ poisoning admitted to Cangzhou Central Hospital between January 2012 and August 2017. Patients were grouped according to short-term treatment (3 mg/kg/day MP for 3 days) or prolonged treatment (3 mg/kg/day MP for 3 days, followed by dosage reduction by half every 3 days, with treatment terminated when a dosage of 0.375 mg/kg/day was reached). Lung function was evaluated at 2 to 3 months after PQ exposure. The forced expiratory volume in 1 second (85.72 ± 4.93% vs 78.41 ± 4.58%; P

Published
2018

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