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Start Over Author "Huai, Bin" Journal medicine
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3. Efficacy of hydroxychloroquine in hand osteoarthritis

Author

Guo-Qing Yang, Yong-Ping Wang, Qiang-Qiang Li, Huai-Bin Zhang, Wen-Qiang Liang, and Ya-Dong Xie

Subjects
medicine.medical_specialty, hydroxychloroquine, Hand Joints, MEDLINE, Cochrane Library, law.invention, 03 medical and health sciences, 0302 clinical medicine, Quality of life, Randomized controlled trial, law, Study Protocol Systematic Review, medicine, Humans, Medical physics, pain, 030212 general & internal medicine, hand function, Protocol (science), business.industry, Hydroxychloroquine, General Medicine, Clinical trial, osteoarthritis, Antirheumatic Agents, 030220 oncology & carcinogenesis, Meta-analysis, Quality of Life, business, medicine.drug, Research Article
Abstract

Background: Symptoms of hand osteoarthritis result in activity limitations and lower quality of life. Hydroxychloroquine, which has been used successfully in the treatment of many autoimmune diseases, can suppress inflammation and might also be beneficial in hand osteoarthritis. Methods: We plan to perform a systematic review and meta-analysis of randomized clinical trial to determine the symptom-modifying effect of hydroxychloroquine in hand osteoarthritis. We will search PubMed, EMBASE, Cochrane Library, and Web of Science using a comprehensive strategy. The related conference proceedings and reference lists of the included studies will also be checked to identify additional studies. Two reviewers will screen retrieved records, extract information and assess the risk of bias independently. Stata v15.1 software will be used to conduct data synthesis. Results: This study will be submitted to a peer-reviewed journal for publication. Conclusion: We hope it will provide a relatively comprehensive reference for clinical practice and future relevant clinical trials. INPLASY registration number: INPLASY2020110005

Published
2020

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