1. Patients with mild paraquat poisoning treated with prolonged low-dose methylprednisolone have better lung function
- Author
-
Gao, Jie, Cao, Zongxun, Feng, Shunyi, Song, Yangying, Bai, Wenjing, Zhao, Shumin, Zhang, Suli, and Li, Yong
- Subjects
Adult ,Male ,Paraquat ,Pulmonary Fibrosis ,Observational Study ,lung function ,Leukopenia ,Methylprednisolone ,Drug Administration Schedule ,Forced Expiratory Volume ,Humans ,Female ,Glucocorticoids ,Research Article ,Retrospective Studies - Abstract
Lung dysfunction is an important characteristic of injury induced by paraquat (PQ). This study aimed to evaluate the effects of prolonged low-dose methylprednisolone (MP) treatment on lung function in patients with mild PQ poisoning. We analyzed the results of lung function testing in all patients with mild PQ poisoning admitted to Cangzhou Central Hospital between January 2012 and August 2017. Patients were grouped according to short-term treatment (3 mg/kg/day MP for 3 days) or prolonged treatment (3 mg/kg/day MP for 3 days, followed by dosage reduction by half every 3 days, with treatment terminated when a dosage of 0.375 mg/kg/day was reached). Lung function was evaluated at 2 to 3 months after PQ exposure. The forced expiratory volume in 1 second (85.72 ± 4.93% vs 78.41 ± 4.58%; P
- Published
- 2018