1. Thoracic [18F]fluorodeoxyglucose uptake measured by positron emission tomography/computed tomography in pulmonary hypertension
- Author
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Armin Frille, Swen Hesse, Alexandra Wald, Hubert Wirtz, Hans-Juergen Seyfarth, Osama Sabri, Sabine Grachtrup, and Karen Steinhoff
- Subjects
Male ,positron emission tomography ,medicine.drug_class ,Hypertension, Pulmonary ,Observational Study ,Standardized uptake value ,030204 cardiovascular system & hematology ,pulmonary glucose uptake ,03 medical and health sciences ,0302 clinical medicine ,Fluorodeoxyglucose F18 ,medicine.artery ,Positron Emission Tomography Computed Tomography ,pulmonary hypertension ,Natriuretic peptide ,Medicine ,Humans ,Lung ,Retrospective Studies ,Fluorodeoxyglucose ,medicine.diagnostic_test ,business.industry ,Myocardium ,General Medicine ,Middle Aged ,medicine.disease ,Pulmonary hypertension ,medicine.anatomical_structure ,Cross-Sectional Studies ,pulmonary end-stage disease ,030228 respiratory system ,Positron emission tomography ,Pulmonary artery ,Vascular resistance ,ComputingMethodologies_DOCUMENTANDTEXTPROCESSING ,Female ,Vascular Resistance ,Radiopharmaceuticals ,business ,Nuclear medicine ,medicine.drug ,Follow-Up Studies ,Research Article - Abstract
Supplemental Digital Content is available in the text, Positron emission tomography (PET) visualizes increased cellular [18F]fluorodeoxyglucose ([18F]FDG) uptake. Pulmonary hypertension (PH) is conceived of a proliferative disease of the lung vessels. Increased glucose uptake can be quantified as pulmonary [18F]FDG uptake via PET imaging. Because the angioproliferative mechanisms in PH are still in need of further description, the aim of the present study was to investigate whether [18F]FDG PET/CT imaging can elucidate these pathophysiologic mechanisms in different etiologies of PH. Patients (n = 109) with end-stage pulmonary disease being evaluated for lung transplant were included in this observational study. Mean standardized uptake value (SUVmean) of predefined regions of interest in lung parenchyma (LP), left (LV), and right ventricle (RV) of the heart, and SUVmax in pulmonary artery (PA) were determined and normalized to liver uptake. These SUV ratios (SUVRs) were compared with results from right heart catheterization (mean pulmonary artery pressure [mPAP], pulmonary vascular resistance [PVR]), and serum N-terminal pro-brain natriuretic peptide. Group comparisons were performed and Pearson correlation coefficients (r) were calculated. The [18F]FDG uptake ratios in LP, RV, RV/LV, and PA, but not in LV, were found to be significantly higher in both patients with mPAP ≥25 mm Hg (P = 0.013, P = 0.006, P = 0.049, P = 0.002, P = 0.68, respectively) and with PVR ≥480 dyn·s/cm5 (P
- Published
- 2016