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Fundamento Describir las concentraciones sericas de ciertas vitaminas y micronutrientes relacionadoscon la respuesta inmunitaria y el sistema antioxidante, en una poblacion de individuoscon infeccion por el virus de la inmunodeficiencia humana (VIH) y determinar su relacioncon la respuesta inflamatoria. Pacientes y metodo Se incluyo a 86 individuos con infeccion por el VIH documentada; divididosen tres grupos (VIH-positivos asintomaticos; sida sin infeccion oportunista y sida con infeccionoportunista activa), que fueron comparados con un grupo control. Se determinaron los valoresplasmaticos de vitamina A, vitamina E, cobre y cinc, asi como parametros inflamatorios. En todoslos pacientes se realizaron pruebas de absorcion de grasas e hidratos de carbono. Resultados Se detectaron valores inferiores a los intervalos de referencia de vitamina A y E enel 36,4 y el 14,3% de los pacientes, respectivamente, y en ninguno de los controles. La prevalenciadel deficit de vitamina A aumento con la gravedad de la enfermedad. La prevalencia depacientes con concentraciones de cobre por debajo de los intervalos de referencia fue inferior ala de los sujetos controles. Los individuos con sida e infeccion oportunista activa presentaronconcentraciones de vitamina A significativamente inferiores (p Conclusiones Los deficit de micronutrientes son prevalentes en individuos con infeccion por elVIH desde estadios iniciales de la enfermedad. La disminucion de la vitamina A y el aumentodel cobre se correlacionan significativamente con parametros inflamatorios, lo que sugiere quesus concentraciones plasmaticas podrian responder mas a la situacion de inflamacion que alpropio estado nutricional.

Our aim was to measure the plasma concentrations of various vitamins and micronutrients involved in the immune response and antioxidant systems of an HIV+ population and to determine how they are related to the inflammatory response.We studied 86 subjects with known HIV-infection who were divided into three groups (asymptomatic HIV+; AIDS without opportunistic infection; and AIDS with active opportunistic infection) which were compared with a control group. Serum concentrations of vitamin A, vitamin E, copper and zinc were measured, as well as several inflammatory parameters. Absorption tests for fat and sugar were performed in all patients.Serum vitamin A and E levels were below the reference range in 36.4% and 14.3% patients, respectively, but not in controls subjects. The prevalence of vitamin A deficiency increased with the severity of the disease. Fewer patients than controls had values below the reference range regarding serum copper. AIDS patients with active opportunistic infection showed significantly lower serum concentrations of vitamin A (p0.001) and significantly higher serum concentrations of copper (p0.0001). Both serum concentrations of vitamin A and copper were correlated with various inflammatory parameters.Micronutrient deficiencies are prevalent in HIV-infected patients including asymptomatic patients. Vitamin A and copper were significantly correlated with inflammatory parameters, suggesting that their serum concentrations have more to do with the inflammatory response than with the nutritional status.