1. Severe Methanol Poisoning with Supralethal Serum Formate Concentration: A Case Report.
- Author
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Nurieva O and Kotikova K
- Subjects
- Adult, Humans, Leucovorin administration & dosage, Male, Renal Dialysis, Ethanol poisoning, Formates blood, Methanol poisoning, Poisoning therapy
- Abstract
Objective: To present a case of survival without visual and central nervous system sequelae at a formate concentration of twice the reported lethal level., Clinical Presentation and Intervention: This was a case of a 33-year-old man who ingested 1 liter of a toxic mixture of methanol and ethanol. Upon admission, he presented with anxiety, tachycardia and hypertension and had a serum formate level of 1,400 mg/l (normal range 0.9-2.1 mg/l), a methanol level of 806 mg/l (normal range 2-30 mg/l), an undetectable ethanol concentration and a normal lactate level. A 10% solution of ethanol and folinic acid was administered intravenously and two 8-hour sessions of intermittent hemodialysis were performed. The patient was discharged on the fifth day without sequelae of poisoning. The follow-up examinations 3 months and 2 years later revealed no damage to the basal ganglia. The patient had normal visual-evoked potential and findings on optical coherence tomography. The genetic analysis revealed a rare minor allele for the gene coding CYP2E1 enzyme of the microsomal ethanol oxidizing system., Conclusion: The patient survived acute methanol poisoning without long-term sequelae despite a high serum level of formic acid upon admission., (© 2015 S. Karger AG, Basel.)
- Published
- 2015
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