1. Cherenkov imaging for total skin electron therapy (TSET)
- Author
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Timothy C. Zhu, John P. Plastaras, Amit Maity, Brian W. Pogue, Tianshun Miao, Jacqueline M. Andreozzi, Petr Bruza, Y. Xie, Heather Petroccia, Lei Dong, and Yihua Zhu
- Subjects
Adult ,Male ,Electron therapy ,Materials science ,Skin Neoplasms ,Photon ,medicine.medical_treatment ,Dose profile ,Electrons ,Radiation beam ,Electron ,Article ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Optics ,Body surface ,medicine ,Humans ,Cherenkov radiation ,Aged ,Aged, 80 and over ,Physics ,business.industry ,Optical Imaging ,Detector ,Radiotherapy Dosage ,General Medicine ,Middle Aged ,Radiation therapy ,030220 oncology & carcinogenesis ,Cathode ray ,Female ,business - Abstract
Background Total skin electron therapy (TSET) utilizes high-energy electrons to treat malignancies on the entire body surface. The otherwise invisible radiation beam can be observed via the optical Cherenkov photons emitted from interactions between the high-energy electron beam and tissue. Methods and materials With a time-gated intensified camera system, the Cherenkov emission can be used to evaluate the dose uniformity on the surface of the patient in real time. Fifteen patients undergoing TSET in various conditions (whole body and half body) were imaged and analyzed. Each patient was monitored during TSET via in vivo detectors (IVD) in nine locations. For accurate Cherenkov imaging, a comparison between IVD and Cherenkov profiles was conducted using a polyvinyl chloride board to establish the perspective corrections. Results and discussion With proper corrections developed in this study including the perspective and inverse square corrections, the Cherenkov imaging provided two-dimensional maps proportional to dose and projected on patient skin. The results of ratio between chest and umbilicus points were in good agreement with in vivo point dose measurements, with a standard deviation of 2.4% compared to OSLD measurements. Conclusions Cherenkov imaging is a viable tool for validating patient-specific dose distributions during TSET.
- Published
- 2019