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PURPOSE Plastic phantoms are commonly used in daily routine for dosimetric tasks in radiation therapy. Although water is the reference medium according to the dosimetric protocols, measurements with nonwater phantoms are easier to be performed. To succeed absorbed dose determination, certain scaling factors have to be applied to the acquired measurements. Taking into account the increased availability of three-dimensional (3D) printing, we attempted to obtain scaling factors for polylactic acid (PLA), a commonly used thermoplastic material for 3D printing. METHODS Measurements were performed with a custom-made phantom from PLA material, which was designed and constructed using 3D printing technology. Depth and fluence scaling factors were obtained within the range of 6 to 20 MeV. Moreover, Monte Carlo simulations were performed to verify the measured results. RESULTS Experimental and Monte Carlo (MC) values showed a good agreement, especially in lower energies. Mean value of depth scaling factor (cpl ) over the whole range of energies was 0.946, while mean fluence scaling factor (hpl ) was found to be 1.050. For energies below 10 MeV, the corresponding mean values for cpl and hpl were 0.946 and 1.054, respectively. CONCLUSIONS PLA phantoms could be constructed and used for electron beam nonreference measurements, reproducing even more complex geometries, from simple quality assurance devices to geometrically complicated anthropomorphic phantoms.