1. Conformal image-guided microbeam radiation therapy at the ESRF biomedical beamline ID17
- Author
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Mattia Donzelli, Elke Bräuer-Krisch, Thierry Brochard, Uwe Oelfke, and Christian Nemoz
- Subjects
Computer science ,Radiography ,medicine.medical_treatment ,Normal tissue ,Synchrotron radiation ,Computed tomography ,Scintigraphy ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Microbeam radiation therapy ,medicine ,Dosimetry ,Irradiation ,Image sensor ,Radiation treatment planning ,medicine.diagnostic_test ,Human head ,business.industry ,Cancer ,Magnetic resonance imaging ,General Medicine ,medicine.disease ,Radiation therapy ,Beamline ,030220 oncology & carcinogenesis ,business ,Nuclear medicine ,Fiducial marker - Abstract
Purpose: Upcoming veterinary trials in microbeam radiation therapy (MRT) demand for more advanced irradiation techniques than in preclinical research with small animals. The treatment of deep-seated tumors in cats and dogs with MRT requires sophisticated irradiation geometries from multiple ports, which impose further efforts to spare the normal tissue surrounding the target. Methods: This work presents the development and benchmarking of a precise patient alignment protocol for MRT at the biomedical beamline ID17 of the European Synchrotron Radiation Facility (ESRF). The positioning of the patient prior to irradiation is verified by taking x-ray projection images from different angles. Results: Using four external fiducial markers of 1.7 mm diameter and computed tomography-based treatment planning, a target alignment error of less than 2 mm can be achieved with an angular deviation of less than 2∘. Minor improvements on the protocol and the use of smaller markers indicate that even a precision better than 1 mm is technically feasible. Detailed investigations concerning the imaging dose lead to the conclusion that doses for skull radiographs lie in the same range as dose reference levels for human head radiographs. A currently used online dose monitor for MRT has been proven to give reliable results for the imaging beam. Conclusions: The ESRF biomedical beamline ID17 is technically ready to apply conformal image-guided MRT from multiple ports to large animals during future veterinary trials.
- Published
- 2016