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Start Over Author "Großgebauer, K." Journal medical hypotheses
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3. Cancer: involvement of replicative origins?

Author

Grossgebauer K

Subjects
Animals, DNA Transposable Elements, DNA, Circular genetics, Eukaryotic Cells physiology, Humans, Models, Genetic, Prokaryotic Cells physiology, RNA-Directed DNA Polymerase genetics, Neoplasms genetics, Replicon
Abstract

The assumption is made that movable genetic elements related to cancer are replicons and/or replicative origins. Some evidence is provided that certain mobile Alu-origins may represent candidates for precursors of chromosomal insertions. They could incorporate and interact with "fixed" chromosomal origins converting them to "procaryotic" ones. In other words, cancer is considered the result of a short and compact "re-evolution" from eucaryotic to "procaryotic" replication units.

Published
1986
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