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Start Over Author "Xinjing Liu" Journal mediators of inflammation
2 results on '"Xinjing Liu"'

1. Increased Th17/Treg Ratio in Poststroke Fatigue

Author

Xinjing Liu, Komal Kenkare, Shanshan Li, Varsha Desai, John Wong, Xun Luo, Lisa J. Wood, Yuming Xu, and Qing Mei Wang

Subjects
Pathology, RB1-214
Abstract

Fatigue is a major debilitating symptom after stroke. The biological mechanisms underlying poststroke fatigue (PFS) are unknown. We hypothesized that PSF is associated with an alteration in the balance between Th17 and Treg cells. To test this hypothesis we assessed fatigue in 30 stroke survivors using the Fatigue Scale for Motor and Cognitive Functions (FSMC). Peripheral blood was collected for assessment of Th17 and Treg cell populations and measurement of interleukin-10 (IL-10). Participants were dichotomized into severe fatigue n=14 and low-moderate fatigue n=16 groups by K-mean cluster analysis of FSMC scores. There were no group differences in age, gender, stroke type, stroke severity, or time since stroke. Stroke survivors in the severe fatigue group reported greater anxiety p=0.004 and depression p=0.001 than in the low-moderate fatigue group. The ratio of Th17 to Treg cells was significantly increased in the severe fatigue group relative to the mild-moderate fatigue group p=0.035. Serum levels of IL-10 negatively correlated withTh17/Treg ratio (r=-0.408, p=0.025). Our preliminary findings suggest that an imbalance in the Th17/Treg ratio is associated with the severity of PSF.

Published
2015
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2. Increased Th17/Treg Ratio in Poststroke Fatigue

Author

Lisa Wood, Xun Luo, Shanshan Li, Yuming Xu, Varsha Desai, Qing Mei Wang, John B. Wong, Xinjing Liu, and Komal Kenkare

Subjects
Oncology, Adult, Male, Sleep Wake Disorders, medicine.medical_specialty, Th17 treg, Article Subject, Immunology, Stroke Type, Anxiety, T-Lymphocytes, Regulatory, Group differences, Internal medicine, lcsh:Pathology, medicine, Humans, Stroke survivor, Stroke, Depression (differential diagnoses), Fatigue, Balance (ability), Aged, Aged, 80 and over, business.industry, Depression, Cell Biology, Middle Aged, medicine.disease, Interleukin-10, Physical therapy, Th17 Cells, Female, medicine.symptom, business, lcsh:RB1-214, Research Article
Abstract

Fatigue is a major debilitating symptom after stroke. The biological mechanisms underlying poststroke fatigue (PFS) are unknown. We hypothesized that PSF is associated with an alteration in the balance between Th17 and Treg cells. To test this hypothesis we assessed fatigue in 30 stroke survivors using the Fatigue Scale for Motor and Cognitive Functions (FSMC). Peripheral blood was collected for assessment of Th17 and Treg cell populations and measurement of interleukin-10 (IL-10). Participants were dichotomized into severe fatiguen=14and low-moderate fatiguen=16groups byK-mean cluster analysis of FSMC scores. There were no group differences in age, gender, stroke type, stroke severity, or time since stroke. Stroke survivors in the severe fatigue group reported greater anxietyp=0.004and depressionp=0.001than in the low-moderate fatigue group. The ratio of Th17 to Treg cells was significantly increased in the severe fatigue group relative to the mild-moderate fatigue groupp=0.035. Serum levels of IL-10 negatively correlated withTh17/Treg ratio (r=-0.408, p=0.025). Our preliminary findings suggest that an imbalance in the Th17/Treg ratio is associated with the severity of PSF.

Published
2015

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