1. Detection of Salivary Interleukin 2 and Interleukin 6 in Patients With Burning Mouth Syndrome
- Author
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Renata Gržić, Miranda Muhvić-Urek, Gordana Brumini, Jelena Horvat, Daria Simčić, and Sonja Pezelj-Ribarić
- Subjects
Interleukin 2 ,Saliva ,medicine.medical_specialty ,Short Communication ,medicine.medical_treatment ,education ,Immunology ,Enzyme-Linked Immunosorbent Assay ,Burning Mouth Syndrome ,BIOMEDICINA I ZDRAVSTVO. Dentalna medicina. Oralna medicina ,interleukin 2 ,interleukin 6 ,saliva ,burning mouth ,Internal medicine ,Severity of illness ,lcsh:Pathology ,medicine ,Humans ,Salivary Proteins and Peptides ,BIOMEDICINE AND HEALTHCARE. Dental Medicine. Oral Medicine ,Interleukin 6 ,Aged ,biology ,Interleukin-6 ,business.industry ,digestive, oral, and skin physiology ,Case-control study ,Cell Biology ,Middle Aged ,Burning mouth syndrome ,stomatognathic diseases ,Cytokine ,Endocrinology ,Gene Expression Regulation ,Case-Control Studies ,Etiology ,biology.protein ,Interleukin-2 ,medicine.symptom ,business ,lcsh:RB1-214 ,medicine.drug - Abstract
The etiology of BMS remains unknown. Role of various cytokines has been implicated in the development of BMS. The aim of this study was to evaluate levels of salivary IL-2 and IL-6 in patients with BMS, compared with age-matched healthy volunteers (control group). Whole saliva from 30 patients with BMS, age range 55–65, was tested for the presence of IL-6 and IL-2 by enzyme immunoassay. Control group consisted of 30 healthy participants, aged 55–65 years. Saliva IL-2 concentrations in BMS were significantly increased in patients compared to healthy subjects: mean34.1±9.7versus7.3±3.0pg/mL;P<.001. Patients with BMS had significantly higher concentrations of IL-6 compared to control: mean30.8±5.6versus5.2±2.8pg/mL;P<.001. In patients with BMS, IL-2 and IL-6 levels in saliva are elevated, correlating with the severity of illness.
- Published
- 2006