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Introduction Students studying to practice medicine require a comprehensive introduction to the endocrine and integumentary systems coupled with sufficient clinical material to illustrate the relevance of this topic in practice. This team-based learning (TBL) module is one of ten modules in a four credit-hour course entitled Basic Histology, which is intended primarily for graduate students seeking entry into medical school. It is taught with the same depth and rigor as the first-year medical histology course at our institution, and in many ways is the equivalent course. Methods Students begin the session having completed assigned readings and a corresponding laboratory session. Students first take a 10-question individual readiness assurance test (iRAT). They then retake this test in groups of five to seven students, to complete the group readiness assurance test (gRAT). Students then stay in these groups as they work through a series of application exercises. Results When administered to 24 students in 2014, the class scores for the iRAT and gRAT were 91.2% and 100.0%, respectively. They scored 88.0% on the group application exercise. Further, 70.8% of students agreed or strongly agreed with the following “Overall, I feel the TBL sessions helped my course grade.” Discussion The students take the TBL process seriously, rarely miss the sessions and seem to feel an obligation to their teammates. They study the relevant learning materials) prior to coming to class, and they demonstrate a good understanding of the subject matter, as evidenced by their iRAT scores. The students also demonstrate effective teamwork, as evidence by their gRAT scores and, more importantly, their performance on the group application exercises.