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Your search keyword '"Fouchier, Ron"' showing total 14 results
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14 results on '"Fouchier, Ron"'

1. Characterization of A/H7 influenza virus global antigenic diversity and key determinants in the hemagglutinin globular head mediating A/H7N9 antigenic evolution

Author

Kok, Adinda, primary, Scheuer, Rachel, additional, Bestebroer, Theo M., additional, Burke, David F., additional, Wilks, Samuel H., additional, Spronken, Monique I., additional, de Meulder, Dennis, additional, Lexmond, Pascal, additional, Pronk, Mark, additional, Smith, Derek J., additional, Herfst, Sander, additional, Fouchier, Ron A. M., additional, and Richard, Mathilde, additional

Published
2023
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3. Analysis of the Evolution of Pandemic Influenza A(H1N1) Virus Neuraminidase Reveals Entanglement of Different Phenotypic Characteristics

Author

Dai, Meiling, primary, Du, Wenjuan, additional, Martínez-Romero, Carles, additional, Leenders, Tim, additional, Wennekes, Tom, additional, Rimmelzwaan, Guus F., additional, van Kuppeveld, Frank J. M., additional, Fouchier, Ron A. M., additional, Garcia-Sastre, Adolfo, additional, de Vries, Erik, additional, and de Haan, Cornelis A. M., additional

Published
2021
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4. Antigenic Drift of the Influenza A(H1N1)pdm09 Virus Neuraminidase Results in Reduced Effectiveness of A/California/7/2009 (H1N1pdm09)-Specific Antibodies

Author

Gao, Jin, primary, Couzens, Laura, additional, Burke, David F., additional, Wan, Hongquan, additional, Wilson, Patrick, additional, Memoli, Matthew J., additional, Xu, Xiyan, additional, Harvey, Ruth, additional, Wrammert, Jens, additional, Ahmed, Rafi, additional, Taubenberger, Jeffery K., additional, Smith, Derek J., additional, Fouchier, Ron A. M., additional, and Eichelberger, Maryna C., additional

Published
2019
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8. Correction for Koel et al., Antigenic Variation of Clade 2.1 H5N1 Virus Is Determined by a Few Amino Acid Substitutions Immediately Adjacent to the Receptor Binding Site

Author

Koel, Björn F., primary, van der Vliet, Stefan, additional, Burke, David F., additional, Bestebroer, Theo M., additional, Bharoto, Eny E., additional, Yasa, I. Wayan W., additional, Herliana, Inna, additional, Laksono, Brigitta M., additional, Xu, Kemin, additional, Skepner, Eugene, additional, Russell, Colin A., additional, Rimmelzwaan, Guus F., additional, Perez, Daniel R., additional, Osterhaus, Albert D. M. E., additional, Smith, Derek J., additional, Prajitno, Teguh Y., additional, and Fouchier, Ron A. M., additional

Published
2014
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9. Antigenic Variation of Clade 2.1 H5N1 Virus Is Determined by a Few Amino Acid Substitutions Immediately Adjacent to the Receptor Binding Site

Author

Koel, Björn F., primary, van der Vliet, Stefan, additional, Burke, David F., additional, Bestebroer, Theo M., additional, Bharoto, Eny E., additional, Yasa, I. Wayan W., additional, Herliana, Inna, additional, Laksono, Brigitta M., additional, Xu, Kemin, additional, Skepner, Eugene, additional, Russell, Colin A., additional, Rimmelzwaan, Guus F., additional, Perez, Daniel R., additional, Osterhaus, Albert D. M. E., additional, Smith, Derek J., additional, Prajitno, Teguh Y., additional, and Fouchier, Ron A. M., additional

Published
2014
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10. Efficient Replication of the Novel Human Betacoronavirus EMC on Primary Human Epithelium Highlights Its Zoonotic Potential

Author

Kindler, Eveline, primary, Jónsdóttir, Hulda R., additional, Muth, Doreen, additional, Hamming, Ole J., additional, Hartmann, Rune, additional, Rodriguez, Regulo, additional, Geffers, Robert, additional, Fouchier, Ron A. M., additional, Drosten, Christian, additional, Müller, Marcel A., additional, Dijkman, Ronald, additional, and Thiel, Volker, additional

Published
2013
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11. Human Coronavirus EMC Does Not Require the SARS-Coronavirus Receptor and Maintains Broad Replicative Capability in Mammalian Cell Lines

Author

Müller, Marcel A., primary, Raj, V. Stalin, additional, Muth, Doreen, additional, Meyer, Benjamin, additional, Kallies, Stephan, additional, Smits, Saskia L., additional, Wollny, Robert, additional, Bestebroer, Theo M., additional, Specht, Sabine, additional, Suliman, Tasnim, additional, Zimmermann, Katrin, additional, Binger, Tabea, additional, Eckerle, Isabella, additional, Tschapka, Marco, additional, Zaki, Ali M., additional, Osterhaus, Albert D. M. E., additional, Fouchier, Ron A. M., additional, Haagmans, Bart L., additional, and Drosten, Christian, additional

Published
2012
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12. Genomic Characterization of a Newly Discovered Coronavirus Associated with Acute Respiratory Distress Syndrome in Humans

Author

van Boheemen, Sander, primary, de Graaf, Miranda, additional, Lauber, Chris, additional, Bestebroer, Theo M., additional, Raj, V. Stalin, additional, Zaki, Ali Moh, additional, Osterhaus, Albert D. M. E., additional, Haagmans, Bart L., additional, Gorbalenya, Alexander E., additional, Snijder, Eric J., additional, and Fouchier, Ron A. M., additional

Published
2012
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14. Robustness of the Ferret Model for Influenza Risk Assessment Studies: a Cross-Laboratory Exercise.

Author

Belser JA, Lau EHY, Barclay W, Barr IG, Chen H, Fouchier RAM, Hatta M, Herfst S, Kawaoka Y, Lakdawala SS, Lee LYY, Neumann G, Peiris M, Perez DR, Russell C, Subbarao K, Sutton TC, Webby RJ, Yang H, and Yen HL

Subjects
Animals, Ferrets, Humans, Laboratories, Lung, Risk Assessment, Influenza A Virus, H1N1 Subtype, Influenza, Human, Orthomyxoviridae Infections
Abstract

Past pandemic influenza viruses with sustained human-to-human transmissibility have emerged from animal influenza viruses. Employment of experimental models to assess the pandemic risk of emerging zoonotic influenza viruses provides critical information supporting public health efforts. Ferret transmission experiments have been utilized to predict the human-to-human transmission potential of novel influenza viruses. However, small sample sizes and a lack of standardized protocols can introduce interlaboratory variability, complicating interpretation of transmission experimental data. To assess the range of variation in ferret transmission experiments, a global exercise was conducted by 11 laboratories using two common stock H1N1 influenza viruses with different transmission characteristics in ferrets. Parameters known to affect transmission were standardized, including the inoculation route, dose, and volume, as well as a strict 1:1 donor/contact ratio for respiratory droplet transmission. Additional host and environmental parameters likely to affect influenza transmission kinetics were monitored and analyzed. The overall transmission outcomes for both viruses across 11 laboratories were concordant, suggesting the robustness of the ferret model for zoonotic influenza risk assessment. Among environmental parameters that varied across laboratories, donor-to-contact airflow directionality was associated with increased transmissibility. To attain high confidence in identifying viruses with moderate to high transmissibility or low transmissibility under a smaller number of participating laboratories, our analyses support the notion that as few as three but as many as five laboratories, respectively, would need to independently perform viral transmission experiments with concordant results. This exercise facilitates the development of a more homogenous protocol for ferret transmission experiments that are employed for the purposes of risk assessment. IMPORTANCE Following detection of a novel virus, rapid characterization efforts (both in vitro and in vivo ) are undertaken at numerous laboratories worldwide to evaluate the relative risk posed to human health. Aggregation of these data are critical, but the use of nonstandardized protocols can make interpretation of divergent results a challenge. For evaluation of virus transmissibility, a multifactorial trait which can only be evaluated in vivo , identifying intrinsic levels of variability between groups can improve the utility of these data, as well as ensure that experiments are performed with sufficient replication to ensure high confidence in compiled results. Using the ferret transmission model and two influenza A viruses, we conducted a multicenter standardization exercise to improve the interpretation of transmission data generated during risk assessment activities; this exercise serves as a model for future efforts employing both in vitro and in vivo models against possible pandemic pathogens.

Published
2022
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