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Your search keyword '"Dixon, Matthew W. A."' showing total 3 results
Start Over Author "Dixon, Matthew W. A." Journal mbio
3 results on '"Dixon, Matthew W. A."'

1. Role of Plasmodium falciparum Protein GEXP07 in Maurer’s Cleft Morphology, Knob Architecture, and P. falciparum EMP1 Trafficking

Author

McHugh, Emma, primary, Carmo, Olivia M. S., additional, Blanch, Adam, additional, Looker, Oliver, additional, Liu, Boyin, additional, Tiash, Snigdha, additional, Andrew, Dean, additional, Batinovic, Steven, additional, Low, Andy J. Y., additional, Cho, Hyun-Jung, additional, McMillan, Paul, additional, Tilley, Leann, additional, and Dixon, Matthew W. A., additional

Published
2020
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2. The Metabolite Repair Enzyme Phosphoglycolate Phosphatase Regulates Central Carbon Metabolism and Fosmidomycin Sensitivity in Plasmodium falciparum

Author

Dumont, Laure, primary, Richardson, Mark B., additional, van der Peet, Phillip, additional, Marapana, Danushka S., additional, Triglia, Tony, additional, Dixon, Matthew W. A., additional, Cowman, Alan F., additional, Williams, Spencer J., additional, Tilley, Leann, additional, McConville, Malcolm J., additional, and Cobbold, Simon A., additional

Published
2019
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3. Role of Plasmodium falciparumProtein GEXP07 in Maurer’s Cleft Morphology, Knob Architecture, and P. falciparumEMP1 Trafficking

Author

McHugh, Emma, Carmo, Olivia M. S., Blanch, Adam, Looker, Oliver, Liu, Boyin, Tiash, Snigdha, Andrew, Dean, Batinovic, Steven, Low, Andy J. Y., Cho, Hyun-Jung, McMillan, Paul, Tilley, Leann, and Dixon, Matthew W. A.

Abstract

The trafficking of the virulence antigen PfEMP1 and its presentation at the knob structures at the surface of parasite-infected RBCs are central to severe adhesion-related pathologies such as cerebral and placental malaria. This work adds to our understanding of how PfEMP1 is trafficked to the RBC membrane by defining the protein-protein interaction networks that function at the Maurer’s clefts controlling PfEMP1 loading and unloading. We characterize a protein needed for virulence protein trafficking and provide new insights into the mechanisms for host cell remodeling, parasite survival within the host, and virulence.

Published
2020
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