1. Use of heparin in the treatment of protein-losing enteropathy after fontan operation for complex congenital heart disease.
- Author
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Kelly AM, Feldt RH, Driscoll DJ, and Danielson GK
- Subjects
- Administration, Cutaneous, Adult, Blood Proteins metabolism, Heparin administration & dosage, Humans, Male, Protein-Losing Enteropathies etiology, Protein-Losing Enteropathies metabolism, Serum Albumin drug effects, alpha 1-Antitrypsin metabolism, Blood Proteins drug effects, Fontan Procedure adverse effects, Heart Defects, Congenital surgery, Heparin therapeutic use, Protein-Losing Enteropathies drug therapy, alpha 1-Antitrypsin drug effects
- Abstract
Protein-losing enteropathy (PLE) is a serious complication of the Fontan operation and is associated with pronounced mortality. Medical management of PLE has been only partially successful. A recent report noted dramatic improvement in patients with PLE within 3 weeks of subcutaneous administration of heparin. We report a case of reversal of PLE with resolution of clinical symptoms and normalization of serum albumin, total protein, and fecal alpha1-antitrypsin values after several months of heparin treatment. Our findings substantiate those recently reported but suggest that reversal of PLE may necessitate more than a few weeks of heparin therapy.
- Published
- 1998
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