1. Silver nanoparticles well-dispersed in amine-functionalized, one-pot made vesicles as an effective antibacterial agent.
- Author
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Deng, Yuanming, Li, Jiefeng, Yu, Junyan, Zhao, Jinlai, and Tang, Jiaoning
- Subjects
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SILVER nanoparticles , *AMINES , *ANTIBACTERIAL agents , *POLYETHYLENE glycol , *FRAGMENTATION reactions , *POLYMERIZATION - Abstract
We report a simple route to prepare silver nanoparticle (Ag NP) loaded amine functionalized poly-oligomeric (ethylene glycol) methyl ether methacrylate block poly-glycidyl methacrylate (POEGMA- b -PGMA) vesicles as an effective antibacterial agent. Self-assemblies of POEGMA- b -PGMA were prepared from reversible addition-fragmentation chain transfer (RAFT) dispersion polymerization mediated by a POEGMA macro-chain transfer agent (macro-CTA) in ethanol. Amine-functionalized self-assemblies were applied for Ag NP loading by using amine and hydroxyl groups as both the coordination agent and reductant under hydrothermal condition in high-pressure steam sterilization. 12.7 wt.% content of fine Ag NP well-dispersed in vesicles showed excellent antibacterial activities with the minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) below 5.0 and 10.0 mg/L against Escherichia coli and 2.5 and 80 mg/L against Staphylococcus aureus respectively. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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