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Abstract Low cycle fatigue (LCF) behavior of CP-Ti along transverse direction under symmetrical strain and stress-controlled modes was compared systematically. For the strain-controlled tests, tension-compression asymmetry (TCA) has little effect on LCF behavior due to the negligible compressive mean stress. For the stress-controlled tests, TCA is detrimental to LCF resistance. The microstructure evolution during cycling deformation was characterized by EBSD and TEM to identify different deformation mechanisms. It was found that strain cycling deformation was dominated by dislocation slip and exhibited the transition from planar slip to wavy slip with the increase of strain amplitude. For the stress-controlled tests, tensile twinning together with dislocation slip accommodated the increased ratcheting deformation. The strain-life curve under stress-controlled tests is lower than that at strain-controlled tests due to the heterogeneous plastic deformation caused by ratcheting deformation. In order to obtain a unified fatigue life prediction model for different control modes, a novel effective strain range related model was proposed by introducing the TCA factor into the original Manson–Coffin relation. Furthermore, the application of this effective strain range related model was extended to the condition of asymmetrical stress cycling by correcting fatigue ductility coefficient and exponent. [ABSTRACT FROM AUTHOR]